Genomic Landscape of Relapsed Acute Lymphoblastic Leukemia

Of the recurrently altered genes, only 87 genes were known to be affected in cancer (Cancer Gene Census, COSMIC database), of which 59 were ...

Read data from Charles Mullighan's laboratory in the Department of Pathology at St. Jude Children's Research Hospital.

Therapy-induced mutations drive the genomic landscape ... - PubMed

To study the mechanisms of relapse in acute lymphoblastic leukemia (ALL), we performed whole-genome sequencing of 103 ...

Therapy-induced mutations drive the genomic landscape of ...

To study the mechanisms of relapse in acute lymphoblastic leukemia (ALL), we performed whole-genome sequencing of 103 ...

Therapy-induced mutations drive the genomic landscape of ...

To study the mechanisms of relapse in acute lymphoblastic leukemia (ALL), we performed whole-genome sequencing of 103 diagnosis-relapse-germline trios and ultra ...

Mutational Landscape and Patterns of Clonal Evolution in Relapsed ...

Relapse of acute lymphoblastic leukemia (ALL) remains a leading cause of childhood cancer-related death. Prior studies have shown clonal mutations at ...

Genomic Determinants of Outcome in Acute Lymphoblastic Leukemia

Genetic subtype, patterns of aneuploidy, and secondary genomic alterations determine risk of relapse in childhood ALL.

Pharmacotypes across the genomic landscape of pediatric acute ...

Contemporary chemotherapy for childhood acute lymphoblastic leukemia (ALL) is risk-adapted based on clinical features, leukemia genomics and ...

Advances in next-generation sequencing for relapsed pediatric ...

Leukemia is one of the most common cancers in children; and its genetic diversity in the landscape of acute lymphoblastic leukemia (ALL) is ...

The Genomic Landscape of Relapsed B-Cell Acute Lymphoblastic ...

618. Acute Lymphoblastic Leukemia: Biology, Cytogenetics and Molecular Markers in Diagnosis and Prognosis: Poster III. The Genomic Landscape of ...

Therapy-induced mutations drive the genomic landscape of ...

1d) concerning the analysis of therapy-induced mutations of relapsed acute lymphoblastic leukemia. The time of relapse onset is indicated as is hypermutator ...

Hématologie - The genomic landscape of adult B-cell precursor ...

... landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 2016;113:11306-11311. 40 ...

Therapy-induced mutations drive the genomic landscape of ...

To study the mechanisms of relapse in acute lymphoblastic leukemia (ALL), we performed whole-genome sequencing of 103 diagnosis-relapse-germline trios and ...

The genomic landscape of pediatric acute lymphoblastic leukemia ...

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer and constitutes approximately 25 % of cancer diagnoses among children under the age ...

The genomic landscape of hypodiploid acute lymphoblastic leukemia

Both near-haploid and low-hypodiploid leukemic cells show activation of Ras-signaling and phosphoinositide 3-kinase (PI3K)-signaling pathways and are ...

Genomic landscape of pediatric B-other acute lymphoblastic ...

P80R was associated with a specific gene expression signature, potentially defining a novel leukemia subtype. Our study shows unbiased European ...

THE GENOMIC LANDSCAPE OF RELAPSED INFANT ... - EHA Library

Keywords: Relapse | Pediatric | Acute lymphoblastic leukemia | KMT2A. THE GENOMIC LANDSCAPE OF RELAPSED INFANT AND CHILDHOOD KMT2A-REARRANGED ACUTE LEUKEMIA.

The genomic landscape of hypodiploid acute lymphoblastic leukemia

CREBBP mutations in relapsed acute lymphoblastic leukaemia. Nature 471, 235–239 (2011). https://doi.org/10.1038/nature09727; Harrison, C.J. et al. Three ...

Therapy-induced mutations drive the genomic landscape of ...

Fingerprint. Dive into the research topics of 'Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia'. Together they ...

The genomic landscape of teenage and young adult T

Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia. Science. 2008;322(5906):1377- 1380. 31. Gutierrez A, Sanda ...