Genomic variants that increase risk of kidney disease are found in ...

The study found that nearly one-third of individuals in these two nations carry APOL1 variants that increase the risk of chronic kidney disease.

Genetic variants increase risk for chronic kidney disease in West ...

They found that having just one risk variant in the APOL1 gene can significantly increase the risk of developing CKD. Results were published ...

The researchers also found that having a risk variant in one copy of the APOL1 gene increases the risk of developing chronic kidney disease, ...

NIH on X: "News: Genomic variants that increase risk of kidney ...

News: Genomic variants that increase risk of kidney disease are found in nearly one-third of West Africans https://t.co/5MBT2HIMWO.

Novel Genetic Variants Associated with Chronic Kidney Disease ...

For instance, genetic variants in the APOL1 increase the risk of many different types of kidney disease in Black individuals, such as hypertension-attributed ESKD or focal segmental glomerulosclerosis. Genome-wide association ...

Genetics and Kidney Disease

Genetic Variants and Kidney Disease Risk ... Some risk variants in certain genes (APOL1, MYH9, HNF1B, SLC7A9 and others) have been linked with an increased risk ...

Genetic Variants Associated with Chronic Kidney Disease ... - Nature

The variant rs1801133 of the MTHFR gene is relatively common and it has been studied for a long time. There is a wide list of disorders in ...

Exploring the impact and utility of genomic sequencing in ...

Whole-exome sequencing (WES) in an older population of kidney disease, 28.3% with positive family history, found a genetic diagnosis for unknown ...

From Risk to Resilience: Tracking a Genetic Variant's Impact on ...

Researchers have discovered that a genetic variant in the APOL1 gene may provide protection against developing CKD in some Black Americans.

Penn Researchers Unlock Genetic 'Treasure Map' for Chronic ...

To better understand the genetic variations associated with kidney disease, researchers have turned to genome-wide association studies (GWAS), ...

Genomic insights into renal diseases: advancements and implications

It was demonstrated that all attributable risk for CKD of the APOL1 locus was associated with SNPs in the last exon of the adjacent APOL1 gene, ...

Increased risk of kidney failure in patients with genetic kidney ... - JCI

There was no effect of the interaction between APOL1 kidney risk ... APOL1 risk variants, race, and progression of chronic kidney disease.

Genetic kidney diseases as an underrecognized cause of chronic ...

There are two fundamental ways in which genetics can explain the family aggregation of CKD. Pathogenic variants in Mendelian genes are rare, but ...

Genetics in chronic kidney disease: conclusions from a Kidney ...

Multiple genetic and environmental risk factors contribute to kidney diseases, making identification of the underlying pathophysiologic ...

Genetic and environmental risk factors for chronic kidney disease

They have been used successfully in nephrology to identify genetic variants associated with important CKD etiologies as well as with kidney function in healthy ...

Genetic variants affecting mitochondrial function provide further ...

Variations in the mitochondrial genome (mtDNA) and nuclear-encoded mitochondrial genes (NEMG) are implicated in susceptibility to kidney disease ...

An intermediate-effect size variant in UMOD confers risk for ... - PNAS

The genetic architecture of chronic kidney disease (CKD) remains incompletely understood. Variants in the kidney-specific gene UMOD cause autosomal dominant ...

Clinical Genetic Testing in Nephrology: Core Curriculum 2024

Patients with a PKD1/PKD2 variant will have more severe kidney disease than those with more uncommon gene variants such as GANAB, ALG8, ALG9, ...

Genomic approaches in the search for molecular biomarkers in ...

A genetic susceptibility to CKD exists although there is limited evidence for the individual gene variants responsible for this risk across the ...

Genetic Susceptibility to Chronic Kidney Disease - Frontiers

Chronic kidney disease (CKD) is a major global health problem with an increasing prevalence partly driven by aging population structure. Both genomic and ...