Genotype Imputation for Admixed Populations

MaCH-Admix: Genotype Imputation for Admixed Populations - NCBI

MaCH-Admix breaks the one-step imputation in MaCH into three steps: phasing, model parameter (including error rate and recombination rate ...

Evaluating the Accuracy of Imputation Methods in a Five-Way ...

Genotype imputation is a powerful tool for increasing statistical power in an association analysis. Meta-analysis of multiple study datasets ...

A population-specific reference panel for improved genotype ...

A crucial component of GWAS is genotype imputation, which requires a large reference panel of sequenced individuals with similar ancestry to the ...

Genotype Imputation for Admixed Populations - UCLA CS

Genetic Epidemiology 00 : 1–13 (2012). MaCH-Admix: Genotype Imputation for Admixed Populations. Eric Yi Liu,1 Mingyao Li,2 Wei Wang,1,3 and Yun Li1,4 ...

MaCH-admix: genotype imputation for admixed populations - PubMed

Imputation in admixed populations is an important problem but challenging due to the complex linkage disequilibrium (LD) pattern.

Imputation accuracy across global human populations - ScienceDirect

By predicting unobserved genotypes based on a reference panel of externally sequenced individuals, imputation increases marker density, improves the statistical ...

Comparing performance of modern genotype imputation methods in ...

Results were compared to evaluate the relative merit of pre-phasing and the usage of admixed references. We showed that the pre-phasing ...

A broad overview of genotype imputation: Standard guidelines ...

It is used in modern genome-wide association studies (GWAS) to extend the number of genetic variants from a set of genotyping microarrays.

Performance and accuracy evaluation of reference panels for ...

Imputation is a widely used technique to statistically predict unobserved genotypes in a single-nucleotide polymorphism (SNP) array dataset ...

Genotype imputation accuracy with different reference panels in ...

Results show that a reference panel that closely matches the ancestry of the study population can increase imputation accuracy, but it can also ...

Rare Variants Imputation in Admixed Populations - Frontiers

IMPUTE2 uses an MCMC algorithm to integrate over the space of possible phase reconstructions for genotypes data. We conducted imputation in non- ...

Strategies for the Genomic Analysis of Admixed Populations

Admixed populations constitute a large portion of global human genetic diversity, yet they are often left out of genomics analyses.

fast data-driven method for genotype imputation, phasing and local ...

Current methods for genotype imputation and phasing exploit the volume of data in haplotype reference panels and rely on hidden Markov models (HMMs). Existing ...

Rapid, Reference-Free human genotype imputation with denoising ...

Genotype imputation is a foundational tool for population genetics. Standard statistical imputation approaches rely on the co-location of ...

Genotype Imputation with Thousands of Genomes - Oxford Academic

Imputation methods work by using haplotype patterns in a reference panel to predict unobserved genotypes in a study dataset, and a number of ...

Evaluation of the imputation performance of the program IMPUTE in ...

Imputation was carried out with the program IMPUTE. The concordance rates between the imputed and observed genotypes were used as a measure of ...

Genotype Imputation for Admixed Populations: MaCH-Admix

Imputation in admixed populations is an important problem but challenging due to the complex linkage disequilibrium (LD) pattern.

MaCH‐Admix: Genotype Imputation for Admixed Populations - OUCI

Imputation in admixed populations is an important problem but challenging due to the complex linkage disequilibrium (LD) pattern.

Assessment of Genotype Imputation Performance Using 1000 ...

This type of approach is particularly attractive for admixed populations and is promoted for its simplistic and practical use for investigators. Imputation in ...

A One-Penny Imputed Genome from Next-Generation Reference ...

Genotype imputation is commonly performed in genome-wide association studies because it greatly increases the number of markers that can be tested for ...