Germline|focused analysis of tumour|detected ...

Germline-focused analysis of tumour-detected ... - Annals of Oncology

1. Germline-focused tumour analysis should be undertaken in all laboratories offering routine analysis of large tumour panels that contain ...

Germline-focused analysis of tumour-detected variants in ... - PubMed

Strategic germline-focused analysis can prioritise a subset of tumour-detected variants for which germline follow-up will produce the ...

Germline-focussed analysis of tumour-only sequencing

A heterozygous germline pathogenic variant in a CSG would be anticipated to be present in 50% of alleles across body tissues, including a tumour. On occasion, ...

Special article Germline-focused analysis of tumour-detected ...

We present updated recommendations around germline follow-up of tumour-only sequencing including (i) revision to 5% for the minimum per-gene GCR.

Germline-Focussed Analysis of Tumour-Only Sequencing

Abstract. It is increasingly common in oncology practice to perform tumour sequencing using large cancer panels. For pathogenic sequence variants in cancer ...

Few People with Cancer Undergo Germline Testing - NCI

Guidelines recommend that germline testing be offered to all people with male breast cancer, ovarian cancer, pancreatic cancer, and metastatic ...

Germline-focussed analysis of tumour-only sequencing - VIVO

Germline-focussed analysis of tumour-only sequencing: recommendations from the ESMO Precision Medicine Working Group.

Germline Genetic Testing After Cancer Diagnosis - JAMA Network

Germline genetic testing after cancer diagnosis was low (6.8%; n = 93 052). Testing was highest in males with breast cancer (50%) and in patients with ovarian ...

(PDF) Germline-Focused Analysis of Tumour-Only Sequencing

Abstract and Figures · 1. Germline-focussed tumour analysis should be carried out in all laboratories as part of routine analysis of a large ...

Erratum to `Germline-focussed analysis of tumour-only sequencing

Distribution of germline and somatic pathogenic variants detected upon tumour analysis. Only variants classified pathogenic/likely pathogenic AND above VAF ...

Assessing actionability and incidental findings of germline variants ...

Paired germline-tumor DNA analysis has emerged as a comprehensive strategy to uncover actionable alterations in advanced cancer patients (ACP) enrolled in ...

Germline-focused analysis of tumour-detected variants in 49,264 ...

Conclusion. Strategic germline-focused analysis can prioritise a subset of tumour-detected variants for which germline follow-up will produce ...

Germline Testing in Patients With Breast Cancer - ASCO Publications

All patients with a personal history of breast cancer diagnosed at age ≤65 years who are without active disease should be offered BRCA1/2 testing if the result ...

Potential pathogenic germline variant reporting from tumor ... - Nature

Germline-focused analysis of tumour-detected variants in 49,264 cancer patients: ESMO Precision Medicine Working Group recommendations. Ann ...

Germline-focused analysis of tumour-detected variants in ... - CoLab

The European Society for Medical Oncology Precision Medicine Working Group (ESMO PMWG) was reconvened to update its 2018/19 recommendations ...

Indications for germline testing in cancer patients

This resource lists the general risk factors and indications for germline testing that should be considered for cancer patients.

Use of Treatment-Focused Tumor Sequencing to Screen for ...

Analysis of 55 formalin-fixed, paraffin-embedded tumor samples for the detection of known germline variants within a subset of cancer- ...

Yield and Utility of Germline Testing Following Tumor Sequencing in ...

The results of this study support the utility of germline analysis both following tumor sequencing and independent of tumor sequencing in appropriate patients.

when somatic tumour testing and germline mutations meet - Nature

An estimated 5–10% of all cancers are hereditary, meaning a single gene mutation contributed to development of the cancer.

Germline-Focused Analysis of Tumour-Only Sequencing - SORA

Here we present analyses of paired sequencing data from 17,152 cancer samples, in which 1494 pathogenic sequence variants were identified across ...