Germline|focussed analysis of tumour|only sequencing

Germline-focussed analysis of tumour-only sequencing - PubMed

It is increasingly common in oncology practice to perform tumour sequencing using large cancer panels. For pathogenic sequence variants in ...

Germline-focussed analysis of tumour-only sequencing

A heterozygous germline pathogenic variant in a CSG would be anticipated to be present in 50% of alleles across body tissues, including a tumour. On occasion, ...

Germline-focused analysis of tumour-detected ... - Annals of Oncology

We present updated recommendations around germline follow-up of tumour-only sequencing including (i) revision to 5% for the minimum per-gene GCR ...

Germline-Focussed Analysis of Tumour-Only Sequencing

Abstract. It is increasingly common in oncology practice to perform tumour sequencing using large cancer panels. For pathogenic sequence variants in cancer ...

Special article Germline-focused analysis of tumour-detected ...

We present updated recommendations around germline follow-up of tumour-only sequencing including (i) revision to 5% for the minimum per-gene GCR.

Germline-focused analysis of tumour-detected variants in 49264 ...

... germline variants detected on tumour-only sequencing, which were based on an analysis of 17,152 cancers. Methods. We analysed an expanded dataset including ...

Tumor-Only Sequencing: A Story Only Half Told - ASCO Publications

The study by Horn et al also highlights how critical the timing of germline analysis can be for the clinical management of patients with ...

Germline-focussed analysis of tumour-only sequencing - VIVO

Germline-focussed analysis of tumour-only sequencing: recommendations from the ESMO Precision Medicine Working Group.

Erratum to `Germline-focussed analysis of tumour-only sequencing

Erratum to 'Germline-focussed analysis of tumour-only sequencing: recommendations from the ESMO Precision Medicine Working Group'. [Annals of Oncology 30 ...

Germline Findings in Tumor-Only Sequencing: Points to Consider ...

Analysis of the cancer genome is most informative when paired with germline genomic DNA to delineate inherited and somatic variants. Although ...

Use of Treatment-Focused Tumor Sequencing to Screen for ...

Analysis of 55 formalin-fixed, paraffin-embedded tumor samples for the detection of known germline variants within a subset of cancer- ...

Yield and Utility of Germline Testing Following Tumor Sequencing in ...

This cohort study examines the prevalence of pathogenic germline variants in patients with cancer who had received DNA sequencing.

Aligning Germline Cancer Predisposition With Tumor-Based Next ...

In a study of MSI in the pan-cancer population of >15,000 patients undergoing parallel tumor-normal sequencing, Lynch syndrome was identified in 16.3% of high- ...

Germline Analysis from Tumor–Germline Sequencing Dyads to ...

The overarching study consent describes the collection and analysis of both tumor and germline tissue including the explicit possibility for identification of ...

Germline Sequencing Analysis to Inform Clinical Gene Panel ...

This genetic association study examines the association between variants of established prostate cancer risk genes and the risk of ...

Erratum to 'Germline-focussed analysis of tumour-only sequencing

Conclusion: Strategic germline-focused analysis can prioritise a subset of tumour-detected variants for which germline follow-up will produce the highest yield ...

Tumour‐only sequencing for oncology management: germline ...

In this review, we will cover analysis for germline variants on large-panel tumour-only testing in cancer patients, along with the emerging issue of whether ...

(PDF) Germline-Focused Analysis of Tumour-Only Sequencing

Abstract and Figures · 1. Germline-focussed tumour analysis should be carried out in all laboratories as part of routine analysis of a large ...

Germline-Focused Analysis of Tumour-Only Sequencing - SORA

Here we present analyses of paired sequencing data from 17,152 cancer samples, in which 1494 pathogenic sequence variants were identified across ...

Tumor‐only sequencing for oncology management: Germline ...

Genes, Chromosomes and Cancer is a cancer genetics journal publishing research on genetic analysis as related to the study of neoplasia and ...