Germline EGFR mutations and familial lung cancer

Germline EGFR Mutations and Familial Lung Cancer

More than half of germline carriers of EGFR T790M were diagnosed with lung cancer by age 60 years, and lung nodules were common in those without ...

Germline EGFR Mutations and Familial Lung Cancer - PubMed

In confirmed or obligate carriers of a germline EGFR PV from 39 different kindreds, 50/91 (55%) were affected with lung cancer with 34/65 (52%) ...

Germline EGFR mutations and familial lung cancer

This is particularly true of the hereditary risk of developing lung cancer. The presence of the epidermal growth factor receptor (EGFR) mutation ...

Germline EGFR mutations in lung cancer (Review) - PMC

EGFR germline mutations, including T790M, V843I, R776H and P848L, have been shown to impact the development of lung cancer. The likelihood of ...

First Prospective Description of Familial EGFR-mutated Lung Cancer

The study team found that in individuals with familial EGFR-mutated lung cancer, lung nodules can be found as early as the third decade of life ...

Familial Lung Cancers Caused by EGFR Germline Mutations

These 22 cases of lung cancer who carried an EGFR germline mutation were associated with strong history of familial lung cancers. In the absence of reported ...

Association of Germline EGFR Mutations With Familial Lung Cancer

Enrichment of germline EGFR T790M was identified in the Southeast United States. Genome-wide haplotyping of 46 germline carriers identified a ...

Inherited lung cancer syndromes targeting never smokers - Yamamoto

Several reports show that germline mutations in the kinase domain of epidermal growth factor receptor (EGFR) such as R776G, R776H, T790M, V843I and P848L, ...

Hereditary Cancer - Lung Cancer Research

Germline EGFR mutations, which have been identified in a handful of cases of familial lung cancer, have the potential to provide insight into EGFR-mutant ...

Mutational Characteristics and Clinical Outcomes for Lung ...

Germline mutations driving lung cancer have been infrequently reported in the literature, with EGFR T790M being a known germline mutation identified in 1% ...

Hereditary Lung Cancer Syndrome Targets Never Smokers with ...

T790M germline mutations are present in 1% of lung cancers undergoing EGFR gene sequencing with the mutant allele occurring in about equal proportion to the ...

Germline EGFR mutations and familial lung cancer. 08/14/2023

In confirmed or obligate carriers of a germline EGFR PV from 39 different kindreds, 50/91 (55%) were affected with lung cancer with 34/65 (52%) ...

A Novel EGFR Germline Mutation in Lung Adenocarcinoma

While most molecular testing focuses on somatic alterations in patients with non-small cell lung cancer, evidence is growing regarding the presence of germline ...

Inherited susceptibility to lung cancer may be associated with the ...

In summary, we report a germline EGFR T790M 'drug–resistance' mutation associated with familial NSCLC, and we note that characteristic EGFR ...

Familial Lung Cancer and the Role of Germline EGFR Mutations

Somatic testing of lung cancers in carriers revealed that 95% had an EGFR driver commutation. Among 36 germline carriers without a cancer ...

Screening for Germline EGFR T790M Mutations Through Lung ...

The study of patients carrying germline endothelial growth factor receptor (EGFR) mutations, which have been found in cases of familial lung adenocarcinoma, ...

Study identifies familial germline EGFR T790M variant in lung cancer

A new familial lung cancer caused by an inherited mutation in EGFR has been described in a study published online Oct. 23 in the Journal of ...

Germline EGFR mutations in lung cancer (Review)

Epidermal growth factor receptor (EGFR) mutations are important events in carcinogenesis. The present study summarized the common germline ...

Germline EGFR Mutations and Familial Lung Cancer | PracticeUpdate

In confirmed or obligate carriers of a germline EGFR PV from 39 different kindreds, 50/91 (55%) were affected with lung cancer with 34/65 (52%) ...

Study Secures EGFR Mutation's Role in Inherited Lung Cancer Risk

In a prospective study, patients with an EGFR T790M somatic mutation at diagnosis had a 50 percent chance of having a germline mutation, ...