Glaucoma Risk Factor Linked to More Than 100 Genetic Loci in ...

Through a meta-analysis of nearly 140000 people, an international team of researchers tied 112 loci to increased intraocular pressure, ...

Large-scale multitrait genome-wide association analyses identify ...

Previous genome-wide association studies have identified over 100 loci for the most common form, primary open-angle glaucoma. Two key glaucoma ...

Large-scale multitrait genome-wide association analyses identify ...

Previous genome-wide association studies have identified over 100 loci for the most common form, primary open-angle glaucoma. Two key glaucoma-associated ...

Researchers identify genes and cell types that may have causal role ...

Using integrative analyses, they identified hundreds of genes and regulatory effects underlying over 100 loci associated with POAG and/or ...

Towards modifying the genetic predisposition for glaucoma: An ...

In the paediatric setting, monogenetic mutations associated with primary congenital glaucoma are the most common cause of disease, accounting for a significant ...

Genome-wide meta-analysis identifies 127 open-angle glaucoma ...

Integration of multiple lines of genetic evidence support the functional relevance of the identified POAG risk loci and highlight potential ...

Examining the Genetic Architecture of Glaucoma

Previous genome-wide association studies have identified more than 100 loci for primary open-angle glaucoma, but much of glaucoma heritability has yet to be ...

glaucoma Genetics & Genomics News | GenomeWeb

Researchers found 46 risk loci associated with primary open-angle glaucoma with the help of a genome-wide association study involving nearly 11,300 cases ...

Understanding the genetics of glaucoma

Apart from variants directly linked to the disease, a large number of genetic loci have been associated with risk factors for POAG, such as ...

Understanding the Genetics Behind Glaucoma - Modern Optometry

Primary open-angle glaucoma constitutes approximately 75% of glaucoma cases and has been linked to 127 genetic loci. Globally, more than 75% of primary angle- ...

Predicting the Future of Genetic Risk Profiling of Glaucoma A ...

have identified more than 100 genes associated with IOP levels.44,45,54,55 ... basis, most glaucoma loci showed a consistent effect across people of ...

Genetics of glaucoma | Human Molecular Genetics - Oxford Academic

Genetic and genomic studies, including genome-wide association studies (GWAS) have accelerated the discovery of genes contributing to glaucoma.

Genetics of primary open-angle glaucoma and its endophenotypes

Several genetic variants were found to be associated with endophenotypes including optic disc parameter and IOP. Moreover, recent studies identified pathologic ...

The Importance of Genetic Biomarkers for Glaucoma

Intraocular pressure is the only modifiable risk factor for POAG. There is strong shared heritability between IOP and POAG, meaning that many ...

A multi-cohort genome-wide association study in African ancestry ...

Primary open-angle glaucoma (POAG), the leading cause of irreversible blindness worldwide, disproportionately affects individuals of African ...

Investigation of Known Genetic Risk Factors for Primary Open Angle ...

The risk of POAG in persons older than 40 is 4- to 5-fold higher in African Americans (4%–5%) than in age-matched Caucasians (1%). ... It is also more severe, ...

Unraveling the genetics of glaucoma - Ophthalmology Times

Apart from variants directly linked to the disease, many genetic loci have been associated with risk factors for POAG, such as intraocular ...

A multi-cohort genome-wide association study in African ancestry ...

46 risk loci significantly associated with glaucoma were ... of genes located in the RGC layer, which is most affected by glaucoma.

Genetic Etiologies of Glaucoma - JAMA Network

Adult-onset forms of glaucoma, including POAG, low-tension glaucoma, and glaucoma associated with pseudoexfoliation, are inherited as complex traits. A positive ...

Molecular Genetics of Glaucoma: Subtype and Ethnicity ... - MDPI

Genes associated with elevated IOP or POAG risk include: ABCA1, AFAP1, ARHGEF12, ATXN2, CAV1, CDKN2B-AS1, FOXC1, GAS7, GMDS, SIX1/SIX6, TMCO1, and TXNRD2.