Glioma|derived plasminogen activator inhibitor|1

Glioma-derived plasminogen activator inhibitor-1 (PAI-1) regulates ...

Glioma-derived macrophage migration inhibitory factor (MIF) promotes mast cell recruitment in a STAT5-dependent manner.

Glioma-derived plasminogen activator inhibitor-1 (PAI-1) regulates ...

PAI-1, a primary regulator in the fibrinolytic cascade is capable of forming a complex with fibrinolytic system proteins together with low- ...

PAI-1 and EGFR expression in adult glioma tumors

The plasminogen activator system, including plasminogen activator inhibitor type 1 (PAI-1), plays a key role in tumor invasion and neoangiogenesis. Epidermal ...

High Serum Level of Plasminogen Activator Inhibitor-1 Predicts ...

Conclusion: These results suggest that the serum PAI-1 level can be a marker for the prediction of histological grade in intracerebral glioma. Gliomas are the ...

EGF regulates plasminogen activator inhibitor‐1 (PAI‐1) by a ...

Since individual tumor cells can invade as deeply as several centimeters into the brain, gliomas are resistant to the established standard ...

Plasminogen Activator Inhibitor-1 in Cancer: Rationale and Insight ...

PA inhibitor-1 (PAI-1) has a paradoxical protumorigenic role in cancer, promoting angiogenesis and tumor cell survival.

Plasminogen activator inhibitor-1 in cancer research - ScienceDirect

PAI-1 is generally accepted to play tumor promoting roles in cancer development and act as a poor prognostic indicator in various cancer types, especially ...

A Narrative Review on Plasminogen Activator Inhibitor-1 and Its ...

PAI-1 in Cancer. Since motile cells focalize uPA on the cell surface through association with uPAR, which is highly expressed on tumor cells, uPA has been ...

Increased levels of plasminogen activator inhibitor-1 (PAI-1) in ...

The complex formation with125I-urokinase demonstrated that PAI-1 complex levels were increased in metastatic and glioblastoma when compared with low-grade ...

Plasminogen Activator Inhibitor-1 Regulates Tumor Growth and ...

We demonstrate that PAI-1 can both inhibit and enhance the growth of M21 human melanoma tumors, apparently by regulating angiogenesis.

The Plasminogen Activator Inhibitor PAI-1 Controls in Vivo Tumor ...

By blocking the interaction between vitronectin (VN), uPAR, and integrins, PAI-1 may induce cell detachment from the extracellular matrix and thereby promote ...

Plasminogen Activator Inhibitor-1 in Tumor Growth, Angiogenesis ...

PAI-1 has been shown to be a potent regulator of both vascular cell migration in vitro and of angiogenesis and tumor growth in vivo.

Functional plasminogen activator inhibitor 1 is retained on the ...

The main plasminogen activators are tissue plasminogen activator (tPA) derived largely from endothelial cells and urokinase (uPA), which is ...

Plasminogen Activator and Inhibitor Activity in Human Glioma Cells ...

Abstract. The activity of the serine protease plasminogen activator (PA), which correlates with tumorigenicity and metastatic capacity, was examined using the ...

Plasminogen Activating Inhibitor-1 Might Predict the Efficacy of Anti ...

In this report, the expression and production of PAI-1 in melanoma patients were evaluated, and the immunomodulatory effects of PAI-1 on tumor-associated ...

The role of plasminogen activator inhibitor-1 in glioblastoma cells

From a molecular standpoint, we have demonstrated that transcriptional repression of PAI-1 leads to the activation of caspases 3/7, indicators ...

Plasminogen Activator Inhibitor-1 Protects Endothelial Cells from ...

Here we provide evidence that PAI-1 is essential to protect endothelial cells (ECs) from FasL-mediated apoptosis. In the absence of host-derived ...

Plasminogen Activator Inhibitor-1 Regulates Tumor Growth and ...

Plasminogen activator inhibitor-1 regulates tumor growth and angiogenesis. Grainne A. McMahon Grainne A. McMahon Affiliations Department of Vascular Biology, ...

Plasminogen activator inhibitor type 1 regulates microglial motility ...

Our results indicate that glia-derived PAI-1 may regulate microglial migration and phagocytosis in an autocrine or paracrine manner.

ACT001, a novel PAI-1 inhibitor, exerts synergistic effects in ... - Nature

To verify the effect of PAI-1 on glioma cells, a PAI-1 knockdown assay was performed. ... Plasminogen activator inhibitor-1 in cancer research.