Glomerular plasmin|like activity in relation to nephritis|associated ...

Glomerular plasmin-like activity in relation to nephritis ... - PubMed

In vitro experimental data indicate that the pathogenic role of NAPlr occurs through its ability to bind to plasmin and maintain its proteolytic activity.

Glomerular Plasmin-Like Activity in Relation to Nephritis-Associated ...

In vitro experimental data indicate that the pathogenic role of NAPlr occurs through its ability to bind to plasmin and maintain its proteolytic activity.

Glomerular plasmin-like activity in relation to nephritis-associated ...

Thus, upregulated glomerular plasmin-like activity in relation to NAPlr deposition in APSGN was identified. This result supports the nephritogenic character of ...

Nephritis-Associated Plasmin Receptor (NAPlr) - MDPI

Moreover, plasmin activity can directly induce glomerular damage via the degradation of ECM proteins such as fibronectin and laminin, and could also exert an ...

Glomerular Plasmin-Like Activity in Relation to Nephritis-Associated ...

Prominent glomerular plasmin-like activity was found in patients who had APSGN and in whom glomerular NAPlr was positive, whereas it was absent ...

Localization of nephritis-associated plasmin receptor in acute ...

In all patients, macrophages showed little staining. Elevated plasmin activity in glomerular neutrophils was identified by combining in situ zymography staining ...

t-PA promotes glomerular plasmin generation and matrix ...

rt-PA colocalized with fibrin along glomerular capillary walls and in the mesangium. Nephritic glomeruli in vitro had decreased plasmin activity, which was ...

The Role of Nephritis‐Associated Plasmin Receptor (NAPlr) in ...

Specifically, plasmin activity of NAPlr-positive neutrophils may damage mesangium and glomerular basement membranes from inner side of ...

[PDF] Glomerular Deposition of Nephritis-Associated Plasmin ...

Glomerular Deposition of Nephritis-Associated Plasmin Receptor (NAPlr) and Related Plasmin Activity: Key Diagnostic Biomarkers of Bacterial Infection-related ...

Glomerulonephritis - Symptoms and causes - Mayo Clinic

... activity alone or other factors. Viral kidney ... https://www.niddk.nih.gov/health-information/kidney-disease/glomerular-diseases.

t-PA promotes glomerular plasmin generation and matrix ...

Plasmin is generated from plasminogen by tissue plasminogen activator (t-PA). We hypothesized that t-PA treatment increases plasmin generation in nephritic ...

Glomerular Deposition of Nephritis-Associated Plasmin Receptor ...

... plasmin receptor. NAPlr deposition and related plasmin activity were observed with a similar distribution pattern in the glomeruli of patients with PSAGN ...

Nephritis-Associated Plasmin Receptor (NAPlr) - ResearchGate

Plasmin trapped by deposited NAPlr triggers the degradation of extracellular matrix proteins, such as glomerular basement membranes and ...

Acute Glomerulonephritis - Medscape Reference

However, the unique glomerular staining patterns of NAPlr and plasmin activity ... Glomerular Deposition of Nephritis-Associated Plasmin Receptor ...

Elevated urinary plasmin activity resistant to α2-antiplasmin in acute ...

Background. A pathogenic role of intraglomerular plasmin bound to nephritogenic antigen (nephritis-associated plasmin receptor, NAPlr) and ...

Urinary Plasminogen as a Marker of Disease Progression in Human ...

The ratio of measured/expected urine plasmin(ogen) was independently associated with ESKD: HR, 0.41 (95% CI, 0.22-0.77) if ratio<0.8 and HR ...

[PDF] Nephritis-Associated Plasmin Receptor (NAPlr): An Essential ...

The disease framework of infection-related glomerulonephritis (IRGN) has been further expanded, and GAPDH of various bacteria other than Streptococci have ...

Proliferative glomerulonephritis with monoclonal immunoglobulin ...

The present cases suggest that evaluation of immunoreactivity for NAPlr and related plasmin activity in glomeruli provides an important clue regarding the ...

Glomerular Deposition of Nephritis-Associated Plasmin Receptor ...

NAPlr deposition and related plasmin activity were observed with a similar distribution pattern in the glomeruli of patients with PSAGN. However, glomerular ...

Nephritis-Associated Plasmin Receptor (NAPlr) - OUCI

Plasmin trapped by deposited NAPlr triggers the degradation of extracellular matrix proteins, such as glomerular basement membranes and mesangial matrix, and ...