Glucose and glutamine fuel protein O|GlcNAcylation to control T cell ...

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell ...

Intracellular proteins are regulated by multiple post-translation modifications. Cantrell and colleagues show that nutrient flux regulates ...

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell ...

We found that glutamine and glucose also fuel an indispensable dynamic regulation of intracellular protein O-GlcNAcylation at key stages of T cell development, ...

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell ...

Sustained glucose and glutamine transport are essential for activated T lymphocytes to support ATP and macromolecule biosynthesis. We found that glutamine ...

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell ...

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy. Swamy M et al. Nature Immunology. 2016 06; 17(6):712-720.

Chemical biology tools to interrogate the roles of O-GlcNAc in ... - NCBI

... of O-GlcNAc in specific immune cell ... Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy.

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell ...

et al. Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation. Immunity 40, 692–705 ( ...

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell ...

Animals; Cell Proliferation; Cell Self Renewal; Cell Transformation, Neoplastic; Clone Cells; Female; Glucose; Glutamine; Lymphocyte Activation; ...

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell ...

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy. Mahima Swamy, Shalini Pathak, Katarzyna M. Grzes, Sebastian ...

Reprogramming of glutamine metabolism and its impact on immune ...

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy. Nat Immunol. 2016;17:712–20. Article CAS ...

Fueling T cell biology | Science Signaling

... of nutrients, including glucose and glutamine. These ... fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy.

Protein synthesis, degradation, and energy metabolism in T cell ...

How T cells control glucose and fatty acid metabolism over the course of ... Glucose and glutamine fuel protein O-GlcNAcylation to control T cell ...

Lymphocyte Glucose and Glutamine Metabolism as Targets of the ...

... of “fuel usage” and transcriptional and posttranscriptional factors that control metabolism in the various activated T cell lineages. The helper T cell ...

Protein O-GlcNAcylation in multiple immune cells and its therapeutic ...

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and Malignancy. Nat Immunol (2016) 17:712–20. doi: 10.1038 ...

GOT1 regulates CD8+ effector and memory T cell generation

... glutamate from glucose with ample amounts of glutamine ... Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and ...

The Role of Non-essential Amino Acids in T Cell Function and Anti ...

Swamy M, Pathak S, Grzes KM et al (2016) Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy.

O-GlcNAcylation and its role in the immune system

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy. Nat Immunol. 2016;17(6):712–20. Article ...

Metabolic pathways in T cell activation and lineage differentiation

Swamy, et al. Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy. Nat. Immunol., 17 (6) (2016), pp. 712-720.

Differential Fuel Requirements of Human NK Cells and Human CD8 ...

... Glutamine Regulates Glucose Uptake in Strongly Activated CD8 T ... Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self- ...

NKT cells adopt a glutamine-addicted phenotype to regulate their ...

... of diversion of glucose into the PPP compared with CD4 T cells. ... Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and ...

13C metabolite tracing reveals glutamine and acetate as critical in ...

However, mature CD8 Teff cells at the peak of expansion reduce their reliance on glucose and glutamine as TCA cycle fuel sources, switching to ...