Glycosaminoglycans enhance complement hemolytic efficiency

In this paper it is postulated that most species of glycosaminoglycans (GAG) restricted non-specific fluid phase complement consumption induced by LIS, an ...

When human serum is diluted and pre-incubated at 37 degrees C in low ionic strength buffer (LIS, u = 0.07; made iso-osmotic with dextrose), a spontaneous ...

Theoretical considerations for GAG-complement-saliva interactions

In this paper it is postulated that most species of glycosaminoglycans (GAG) restricted non-specific fluid phase complement consumption induced by LIS, an ...

Glycosaminoglycans enhance complement hemolytic efficiency ...

Glycosaminoglycans enhance complement hemolytic efficiency: Theoretical considerations for GAG-complement-saliva interactions ... hemolytic activity of complement ...

Glycosaminoglycans enhance complement hemolytic efficiency ...

Dive into the research topics of 'Glycosaminoglycans enhance complement hemolytic efficiency: Theoretical considerations for GAG-complement-saliva interactions' ...

(PDF) Glycosaminoglycans enhance complement hemolytic ...

Glycosaminoglycans enhance complement hemolytic efficiency: Theoretical considerations for GAG-complement-saliva interactions.

Defining the Glycosaminoglycan Interactions of Complement Factor ...

The pattern and degree of sulfation influenced FHR5–GAG interactions. Surface heparan sulphate enhanced the ability of FHR5 to limit FH binding to C3b.

Citations to Structural Determinants of the Capacity of Heparin ... - JCI

Glycosaminoglycans enhance complement hemolytic efficiency: Theoretical considerations for GAG-complement-saliva interactions. C Nan-Shan, RJ Boackle, Molecular ...

Complement biology for hematologists - Wiley Online Library

It is noteworthy that in hematological diseases associated with acute hemolysis episodes, the activation of the AP may be enhanced by the ...

Role of GAGs and Sialic Acid in Complement Regulation - Frontiers

A number of complement regulators, such as factor H and properdin, interact with sugar molecules, such as glycosaminoglycans (GAGs) and sialic acid, on host and ...

Dual interaction of factor H with C3d and glycosaminoglycans in ...

Results of these indicate how only two complement proteins, C3b and FH, can perform efficient target recognition. aHUS mutations in FH19, FH20, ...

Hemolysis is associated with altered heparan sulfate of the ...

Strongly reduced HS density was significantly associated with both hemolysis at the time of biopsy and local complement activation (C3 and/or ...

Inhibition of equine complement activity by polysulfated ...

Difference was not apparent in the extent of inhibition of complement from each of the 4 horses tested. Polysulfated glycosaminoglycans appeared to inhibit the ...

The Role of the Complement System in the Pathogenesis of ... - MDPI

In turn, FH inhibits the activation of FXI by thrombin or FXIIa. A complex of FH with FXIIa was detected in plasma [89]. Evidence suggests that FH may promote ...

Therapeutic Lessons to be Learned From the Role of Complement ...

FHmoss has full biological activity and was shown to reduce complement activation and hemolysis in aHUS patient sera. ... enhance therapeutic efficacy of the ...

Direct activation of the alternative complement pathway by SARS ...

Complement-dependent killing using the modified Ham test is blocked by either C5 or factor D inhibition. C3 fragments and C5b-9 are deposited on ...

All Things Complement : Clinical Journal of the American Society of ...

Other diseases, such as atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G), are associated with defective regulation and/or enhanced ...

Self‐nonself discrimination by the complement system - Meri - 2016

In hemolytic uremic syndrome, they promote complement attack against blood cells and vascular endothelial cells and lead, for example, to ...

A synthetic protein as efficient multitarget regulator against ... - Nature

One important feature of complement regulators is the ability to bind to polyanions such as glycosaminoglycans and sialic acids on host cell ...

Essential Role of Surface-Bound Complement Factor H in ...

This domain of fH is necessary for fH interactions with surface-bound C3b/C3d as well as cell surface glycosaminoglycans. rfH19-20 efficiently competes with ...