HLA|DR4 in insulin|dependent diabetic parents and their ...

HLA-DR4 in insulin-dependent diabetic parents and their ... - NCBI

The transmission of predominantly DR4 from affected parents to affected offspring suggests that susceptibility to IDDM is inherited primarily via a single dose ...

HLA-DR4 in insulin-dependent diabetic parents and their ... - NCBI

HLA-DR4 in insulin-dependent diabetic parents and their diabetic offspring: A clue to dominant inheritance. (genetics of type I diabetes/HLA-associated ...

HLA-DR4 in insulin-dependent diabetic parents and ... - Europe PMC

The transmission of predominantly DR4 from affected parents to affected offspring suggests that susceptibility to IDDM is inherited primarily via a single dose ...

Preferential Transmission of Diabetic Alleles within the HLA Gene ...

These data suggest that differential parental transmission of the HLA-DR4-linked diabetes-predisposing allele may explain the higher risk of diabetes.

Excess of maternal HLA-DR3 antigens in HLA DR3,4 positive Type ...

The susceptibility determinants of Type 1 (insulin-dependent) diabetes mellitus are known to be associated with both HLA-DR3 and DR4. In our study we wished ...

Genetics of Diabetes - American Diabetes Association

For example, most white people with type 1 diabetes have genes called HLA-DR3 or HLA-DR4, which are linked to autoimmune disease. If you and your child are ...

Shared genetic susceptibility of Type 1 (insulin-dependent) and ...

An earlier report cited a contribution by the haptoglobin locus to genetic susceptibility for Type 2 diabetes. We provide evidence that a high risk HLA antigen ...

HLA-DP and Susceptibility to Insulin-Dependent Diabetes Mellitus in ...

It is known that certain combinations of alleles within the Human Leukocyte Antigen (HLA) Complex are associated with susceptibility or resistance to insulin- ...

Parental Origin of Diabetes-Associated HLA Types in Sibling Pairs ...

Genetic susceptibility to type I diabetes is partly deter- mined by genes located in the human leukocyte antigen. (HLA) region on chromosome 6.

HLA-DR4 in insulin-dependent diabetic parents and their diabetic ...

Insulin-dependent diabetes mellitus (IDDM) susceptibility determinants are known to be associated with both HLA-DR3 and -DR4. We monitored the inheritance ...

The Predisposition to Type 1 Diabetes Linked to the Human ...

We present evidence for a second disease locus linked to, but distinct from, the classic HLA class II loci. Allele 3 of marker D6S2223, 5.5 Mb telomeric of the ...

Genetic aspects of type 1 diabetes

The HLA is located on chromosome 6p21 and encodes class I and class II genes. Class I genes, including HLA-A, HLA-B, and HLA-C are at the ...

Extreme genetic risk for type 1A diabetes - PNAS

Despite sharing both HLA haplotypes with their proband, siblings without the HLA DR3/4-DQ8 genotype had only a 25% risk for T1D by age 12. The risk for T1D in ...

Parental Origin of Diabetes-Associated HLA Types in Sibling Pairs ...

Fathers are reported to transmit HLA-DR4 haplotypes more frequently to their diabetic offspring than mothers. More recently, it has been ...

Association between HLA-DQB1 Alleles and Type 1 Diabetes in a ...

The human leukocyte antigen (HLA) system plays a crucial role in the autoimmune process leading to childhood diabetes. The purpose of this study was to evaluate ...

Analysis of Families at Risk for Insulin-Dependent Diabetes Mellitus ...

Analysis of IDDM families reveals that HLA genes not only predispose to islet autoimmunity but influence progression to clinical disease. The ...

THE IMMUNOGENETICS OF INSULIN-DEPENDENT DIABETES

The best single marker for IDDM is based on amino acid polymorphism of the HLA-DQ gene. Current evidence, however, indi cates that the MHC susceptibility to ...

Genetics and Type 1 Diabetes - WebMD

Since type 1 diabetes is an autoimmune disease -- your body destroys the cells that make insulin -- it makes sense that HLA genes are front and ...

Genetics of Type 2 Diabetes—Pitfalls and Possibilities - MDPI

The main susceptibility genes currently accepted for T1D are the HLA class II alleles, which account for up to 50% of genetic T1D risk and non-HLA loci ...

Type 1 diabetes - Genetics - MedlinePlus

Insulin controls how much glucose (a type of sugar) is passed from the blood into cells for conversion to energy. Lack of insulin results in the ...