HSD17B13 truncated variant is associated with a mild hepatic ...

HSD17B13 encodes hydroxysteroid 17-β dehydrogenase 13, a novel liver lipid-droplet associated protein that is involved in the regulation of ...

Background & Aims. HSD17B13 encodes hydroxysteroid 17-β dehydrogenase 13, a novel liver lipid-droplet associated protein that is involved in the regulation of ...

HSD17B13 truncated variant is associated with a mild hepatic ...

Semantic Scholar extracted view of "HSD17B13 truncated variant is associated with a mild hepatic phenotype in Wilson's Disease" by P. Ferenci et al.

A Protein-Truncating HSD17B13 Variant and Protection from ...

A loss-of-function variant in HSD17B13 is associated with a reduced risk of chronic liver disease and of progression from steatosis to steatohepatitis.

(PDF) HSD17B13 truncated variant is associated with a mild hepatic ...

A protein-truncating HSD17B13 variant (rs72613567) was shown to protect individuals from alcoholic and non-alcoholic liver disease. Since ...

Inhibition of HSD17B13 protects against liver fibrosis by ... - PNAS

A loss-of-function variant in hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13) is associated with decreased liver fibrosis, but the underlying mechanisms ...

A phase I/II study of ARO-HSD, an RNA interference therapeutic, for ...

HSD17B13 loss-of-function mutations are protective against alcohol-related and non-alcoholic liver disease, including NASH. · ARO-HSD is a hepatocyte-targeted ...

An HSD17B13 variant reduces cirrhosis risk - Nature

A newly identified gene variant reduces risk of chronic liver disease (CLD) and cirrhosis, according to a new study.

[PDF] A Protein‐Truncating HSD17B13 Variant and Protection from ...

A loss‐of‐function variant in HSD17B13 was associated with a reduced risk of chronic liver disease and of progression from steatosis to steatohepatitis.

HCV-Associated Liver Fibrosis and HSD17B13

Despite the astonishing advances in hepatitis C virus (HCV) treatment, HCV remains a major source of chronic liver disease.

Association of HSD17B13 rs72613567: TA allelic variant with liver ...

Besides, the HSD17B13 rs72613567:TA allelic variant can also provide protection from nonalcoholic fatty liver disease (NAFLD) not only in entire ...

Loss-of-function HSD17B13 variants, non-alcoholic steatohepatitis ...

17β-hydroxysteroid dehydrogenase 13 (HSD17B13) variants were recently reported to have significantly lower odds of non-alcoholic fatty liver ...

Structural basis of lipid-droplet localization of 17-beta ... - Nature

Hydroxysteroid 17-beta-dehydrogenase 13 (HSD17B13) is a hepatic lipid droplet-associated enzyme that is upregulated in patients with ...

Hydroxysteroid 17-β dehydrogenase 13 variant increases ...

HSD17B13 is a lipid droplet–associated protein (3, 6), mainly expressed in the liver (7). It is a target gene for the insulin-regulated ...

Effect of donor HSD17B13 genotype on patient survival after liver ...

Variants in PNPLA3 and HSD17B13 are well described genetic risk factors that influence chronic liver disease progression. A few previous studies ...

Decoding 17-Beta-hydroxysteroid Dehydrogenase 13

Moreover, the rs72613567:TA variant has been associated with reduced liver enzyme levels and improved survival in HCC patients. Integrating this ...

Interplay of PNPLA3 and HSD17B13 Variants in Modulating the Risk ...

In conclusion, HSD17B13:TA mitigates the increased risk of liver fibrosis progression and HCC in HCV-infected patients with PNPLA3 I148M variant ...

Splice variant rs72613567 prevents worst histologic outcomes in ...

Hydroxysteroid 17-#x03B2; dehydrogenase 13 (HSD17B13) is a lipid droplet-associated protein; its gene-encoding variants affect the chronic liver diseases, ...

Genetic variant rs72613567 of HSD17B13 gene reduces alcohol ...

Two variants of HSD17B13, rs72613567 and rs6834314 (high linkage with each other) were found to reduce the risk of alcohol-related liver disease ...

A Protein-Truncating HSD17B13 Variant and Protection from ...

Results A splice variant (rs72613567:TA) in HSD17B13, encoding the hepatic lipid droplet protein hydroxysteroid 17-beta dehydrogenase 13, was associated with ...