High Levels of Within|Host Variations of Human Papillomavirus 16 ...

High Levels of Within-Host Variations of Human Papillomavirus 16 ...

Some within-host variations of E1/E2 present at high levels in ICC may be positively selected for and contribute to cervical cancer development.

High Levels of Within-Host Variations of Human Papillomavirus 16 ...

Human papillomavirus type 16 (HPV16) is the most common HPV genotype found in invasive cervical cancer (ICC). Recent comprehensive genomics ...

Within-Host Variations of Human Papillomavirus Reveal APOBEC ...

The whole genomes of HPV types 16, 52, and 58 were amplified by type-specific PCR from total cellular DNA of cervical exfoliated cells collected ...

Human papillomavirus genomics: Understanding carcinogenicity

Over the last decade, HPV whole genome sequencing has established that even fine-scale within-type HPV variation influences precancer/cancer risks, and that ...

Genetic variation within the human papillomavirus type 16 genome ...

We found eight HPV16 SNPs to be strongly associated with HPV-OPC prognosis. •. Median survival was 4 years for HPV-OPC patients with ≥1 high- ...

Changes in intrahost genetic diversity according to lesion severity in ...

Human papillomavirus type 16 (HPV16) is the most common cause of cervical cancer, but most infections are transient with lesions not ...

Chapter 11: Human Papillomavirus | Pink Book - CDC

High-risk HPV types are detected in 99% of cervical precancers. Type 16 is the cause of approximately 50% of cervical cancers worldwide, and ...

Long-read sequencing unveils high-resolution HPV integration and ...

Contrary to the episomal state during the normal infectious cycle, high-risk HPV DNA is often integrated into the host genome during persistent ...

Human Papillomavirus Type 16 - an overview | ScienceDirect Topics

Among well categorized 80 types, the high-risk types HPV's 16 and 18 are highly involved in 70% of cervical cancer. The virulence of HPV is mainly exhibited by ...

HPV Strains | Only Small Number Cause Problems

Infection with high-risk HPV (hrHPV) types that are not cleared by the immune system can cause cervical cancers and a significant proportion of cancers of the ...

HPV and Cancer - NCI

High-risk HPVs can cause several types of cancer. There are 12 high-risk HPV types: HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59.

Human papillomavirus type 16 genomic variation in women with ...

In a national register-based nested case–control study, we retrieved archival smears from baseline cytologically normal women who later ...

Intra-Patient Genomic Variations of Human Papillomavirus Type 31 ...

Human papillomavirus type 31 (HPV31) is detected less frequently in cervical cancer than two major causative types, HPV16 and HPV18.

Functional variants of human papillomavirus type 16 demonstrate ...

Having a tropism for mucosal tissues, high-risk HPVs are detected in nearly all cervical cancers. HPV16 is the most common high-risk type but ...

Diversifying Selection in Human Papillomavirus Type 16 Lineages ...

Of the high-risk HPV types associated with cervical cancer, HPV16 is the most prevalent and is found in approximately half of all cancers (7, 49). Numerous ...

The human papillomavirus replication cycle, and its links to cancer ...

HPV16 (HR-HPV genotype 16) is the most prevalent worldwide and the major cause of HPV-associated cancers. At the molecular level, cancer progression is due to ...

Genetic variation within the human papillomavirus type 16 genome ...

Conclusions HPV16 genetic variation is associated with HPV-OPC prognosis and can improve prognostic accuracy. INTRODUCTION. The incidence of ...

18: Human Papillomavirus Genomics: Past, Present and Future

HPV-16 and HPV-18 are highly prevalent, oncogenic types implicated in 70% of cervix cancer, and as members of different species groups they exhibit different ...

Genomic Variation of Human Papillomavirus Type 16 and Risk for ...

However, HPV16 is also the most common type of HPV in the normal population, and only a minority of women with HPV16 infection develop cervical cancer. Studies ...

Whole-Genome Sequencing of HPV 16 Reveals New Criterion for ...

A large genomic analysis of human papillomavirus (HPV) shines new light on the influence of viral genetic diversity on carcinogenicity of the high-risk type ...