How ecDNA Fuels Cancer by Breaking the Laws of Biology

How ecDNA Fuels Cancer by Breaking the Laws of Biology - HHMI

DNA belongs in chromosomes, but some tumors stow cancer-promoting genes outside chromosomes, as ecDNA. New research explores how ecDNA ...

Extrachromosomal DNA Fuels Cancer by Breaking the Laws of ...

DNA belongs in chromosomes, but some tumors stow cancer-promoting genes outside chromosomes, as extrachromosomal DNA (ecDNA).

How ecDNA Fuels Cancer by Breaking the Laws of Biology | HHMI

Typically restricted to chromosomes, cancer cells have the ability to store genes that encourage cancer growth in extrachromosomal DNA ...

Extra chromosomal DNA in tumours fuels cancer growth | PET

Sources and References · How ecDNA fuels cancer by breaking the laws of biology · Scientists expose targetable 'rogue' tumour DNA · Origins and ...

How ecDNA Fuels Cancer by Breaking the Laws of Biology

Normal human cells generally keep their DNA in chromosomes. But that's hardly the only way ecDNA disregards norms. Research by Chang and ...

The ecDNA story – catching the mastermind behind cancer evolution

A cancer cell undergoing mitosis, or cloning itself and splitting in two. Cancer cells divide faster than healthy cells. Every time that happens ...

Coordinated inheritance of extrachromosomal DNAs in cancer cells

Distinct ecDNA sequences, termed ecDNA species, can co-exist to facilitate intermolecular cooperation in cancer cells. How multiple ecDNA ...

Cracking the code of DNA circles in cancer, Stanford Medicine-led ...

Tiny circles called ecDNA are critical in cancer development and drug resistance. An international Stanford Medicine-led team publishes ...

HHMI: Advancing Scientific Research & Education

DNA belongs in chromosomes, but some tumors stow cancer-promoting genes outside chromosomes, as ecDNA. New research explores how ecDNA violates genetic norms to ...

Extrachromosomal DNA amplifications in cancer - PMC - NCBI

Thus, even though ecDNA replicates once per cell cycle, it does not follow most rules of mitotic inheritance, enabling tumours to rapidly evolve ...

Enhancing transcription–replication conflict targets ecDNA-positive ...

ecDNAs can arise during the transition to, development and progression of cancers, and they exhibit unique biological features that provide ...

Extrachromosomal DNA: Biogenesis and Functions in Cancer

ecDNA are common in many of the most aggressive forms of cancer ... Annual Review of Cancer Biology · Volume 8, 2024; Article. Annual Review ...

Extrachromosomal DNA (ecDNA): an origin of tumor heterogeneity ...

The genome of cancer cells contains circular extrachromosomal DNA (ecDNA) elements not found in normal cells. Analysis of clinical samples ...

Scientists aim to disrupt DNA rings that block cancer treatments

Chang describes the circles as vicious gangs that terrorize the chromosome-bound genome by ignoring all the understood rules of biology, making ...

Disparate Pathways for Extrachromosomal DNA Biogenesis and ...

Oncogene amplification on extrachromosomal DNA (ecDNA) is a pervasive driver event in cancer, yet our understanding of how ecDNA forms is limited. In this ...

Review Extrachromosomal DNA—relieving heredity constraints ...

Oncogene amplification on extrachromosomal DNA (ecDNA) provides a mechanism by which cancer cells can rapidly adapt to changes in the tumour microenvironment.

Extrachromosomal DNA—relieving heredity constraints ...

Oncogene amplification on extrachromosomal DNA (ecDNA) provides a mechanism by which cancer cells can rapidly adapt to changes in the tumour ...

sandypriester on X: "How ecDNA Fuels Cancer by Breaking the ...

How ecDNA Fuels Cancer by Breaking the Laws of Biology - Howard Hughes Medical Institute https://t.co/V8Nnidvh5G via @GoogleNews.

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HHMI.ORG · How ecDNA Fuels Cancer by Breaking the Laws of Biology | HHMI ·...

Extrachromosomal DNA and Cancer Development with King Hung

... (ecDNA) and cancer drug development. King went to college at the University of Washington where he became passionate about developmental biology.