How location and cellular signaling combine to activate the NLRP3 ...

NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) is a cytosolic innate immune sensor of cellular stress signals, triggered by infection and ...

NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) is a cytosolic innate immune sensor of cellular stress signals, triggered by infection and sterile ...

How location and cellular signaling combine to - ProQuest

Upon detection of an activating stimulus, NLRP3 transitions from an inactive homo-oligomeric multimer into an active multimeric inflammasome, which promotes the ...

How location and cellular signaling combine to activate the NLRP3 ...

AbstractNOD-, LRR-, and pyrin domain-containing 3 (NLRP3) is a cytosolic innate immune sensor of cellular stress signals, triggered by infection and sterile ...

The mechanism of NLRP3 inflammasome activation and its ...

Following the priming step, NLRP3 is activated by a second signal and initiates its self-oligomerization, activated NLRP3 forms inflammasome together with ASC ...

The NLRP3 Inflammasome Pathway: A Review of Mechanisms and ...

Upon activation by PAMPs and DAMPs, NLRP3 oligomerizes and activates caspase-1 which initiates the processing and release of pro-inflammatory cytokines IL-1β ...

Squaramides enhance NLRP3 inflammasome activation by lowering ...

Inflammasome activation also results in pyroptosis, a form of inflammatory cell death [1]. The best studied inflammasome is formed by the ...

Reframing the link between metabolism and NLRP3 inflammasome

Priming (step 1) licenses the cell for NLRP3 inflammasome activation. Certain PAMPs and cytokines (CK) bind to their receptors, e.g.: LPS/TLR4, TNF-α/TNFR or IL ...

Dr. Róisín McManus on LinkedIn: How location and cellular ...

Dr. Róisín McManus' Post · How location and cellular signaling combine to activate the NLRP3 inflammasome - Cellular & Molecular Immunology · More ...

The NLRP3 inflammasome: molecular activation and regulation to ...

The authors describe the complex pathways controlling the NLRP3 inflammasome activation and regulation and how it is being targeted to treat inflammatory ...

NLRP3 Inflammasome - an overview | ScienceDirect Topics

NLRP3 stimulation leads to activation of caspase-1, the secretion of pro-inflammatory cytokines and an inflammatory cell death called pyroptosis. Effectors of ...

Cell volume regulation modulates NLRP3 inflammasome activation.

How location and cellular signaling combine to activate the NLRP3 inflammasome · Anil AkbalAlesja DernstM. LovottiM. ManganR. McManusE. Latz. Biology, Medicine.

Truncating NFKB1 variants cause combined NLRP3 inflammasome ...

In addition to activating signals, NF-κB provides also negative feedback regulation of inflammasome activity by inducing expression of an ...

NLRP3 inflammasome assembly is regulated by phosphorylation of ...

NLRP3 is a cytosolic pattern recognition receptor that senses microbes and endogenous danger signals. Upon activation, NLRP3 forms an ...

How location and cellular signaling combine to activate the NLRP3 ...

Affiliations. NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) is a cytosolic innate immune sensor of cellular stress signals, triggered by ...

Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine ...

How the activation of gene transcription by signaling receptors enables NLRP3 activation remains elusive and controversial. In this study, we show that cell ...

AKT Regulates NLRP3 Inflammasome Activation by ... - OUCI

Abstract The cytosolic pattern recognition receptor NLRP3 senses host-derived danger signals and certain microbe-derived products in both humans and rodents ...

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic ...

We and others recently documented how in addition to necroptotic cell death, MLKL signaling also triggers activation of the nucleotide-binding oligomerization ...

S-acylation of NLRP3 provides a nigericin sensitive gating ... - eLife

NLRP3 is an inflammasome seeding pattern recognition receptor activated in response to multiple danger signals which perturb intracellular ...

Butyrate and propionate are microbial danger signals that activate ...

SCFA-driven NLRP3 activation was potassium efflux independent and did not result in cell death but rather triggered hyperactivation and IL-1β release. Our ...