How to study lncRNA expression and modifications

How to Study LncRNA Expression and Modifications? - Arraystar

Yet, with their important roles in gene regulation, cell proliferation/differentiation, organism development, biological pathways, and disease pathogenesis, ...

Techniques for investigating lncRNA transcript functions in ...

... changes in gene expression [71–73]. The nuclear-enriched lncRNA ... term functional studies of the target lncRNA. Furthermore, in vivo ...

How to study lncRNA expression and modifications - YouTube

LncRNAs make up a long non-coding portion of the transcriptome, often expressed at low levels. Yet, with their important roles in gene ...

Approaches for Understanding the Mechanisms of Long Noncoding ...

The best-studied lncRNA is Xist, which orchestrates X-chromosome inactivation (XCI), an essential developmental process that ensures proper expression balance ...

Methods for studying non-coding RNA - Nature

... expression, localization, processing fates and modifications of known and previously unannotated RNAs. Sarah Djebali; Carrie A. Davis; Thomas ...

Why and How to Study LncRNAs? | Arraystar

The majority of genomes are transcribed to produce LncRNAs. LncRNA's expression is under precise control at all levels during gene expression and processing.

Long noncoding RNA study: Genome-wide approaches

Transcription start sites (TSSs) identified by cap analysis of gene expression (CAGE) as well as cleavage and polyadenylation sites (CPSs) determined using poly ...

Long non-coding RNAs: definitions, functions, challenges and ...

Deletion of brain cytoplasmic RNA 1 (BC1), a highly expressed brain lncRNA, is seemingly harmless in mice but results in behavioural changes ...

Modulating the expression of long non‐coding RNAs for functional ...

Bioinformatic studies have annotated tens of thousands of lncRNAs—transcripts > 200 nt in length that do not appear to code for proteins—and ...

Platforms for Investigating LncRNA Functions - ScienceDirect

Conventional gene modifications involving RNA interference (RNAi) techniques such as small interfering RNA (siRNA) have been used extensively to study functions ...

expression of long non-coding RNAs is associated with H3Ac and ...

Collectively, our results revealed that the expression of lncRNAs is associated with H3Ac/H3K4me2 changes regulated by the HDA6-LDL1/2 histone ...

Identifying and functionally characterizing tissue-specific and ...

Similar to previous studies, we found that lncRNAs had lower expression than protein coding genes [10, 12] (Supplementary Figure S1A). After ...

Gene regulation by the act of long non-coding RNA transcription

Transcriptional regulation by lncRNAs could work either in cis or in trans, and could negatively or positively control pc gene expression.

Integrated Analysis of lncRNA and mRNA Expression Profiles ...

Studies have shown that lncRNAs play important roles in the aging process of tissues and organs. For example, the expression of lncRNA H19 is downregulated ...

Long non-coding RNA identification over mouse brain development ...

The study not only supports the biological hypothesis that chromatin can regulate expression of tissue-specific or developmental stage-specific lncRNAs but also ...

Discover lncRNA: Understanding the Long Noncoding Transcriptome

Learn about the exciting new field of long noncoding RNA (lncRNA) and how this newly discovered class of RNA compares to messenger RNA ...

Workflow of LncRNA Sequencing and Its Data Analysis

Dynamicity: LncRNA sequencing serves as a powerful tool for studying the dynamic expression patterns of lncRNAs, encompassing changes across different ...

What is the best way for profiling long non-coding RNAs: RNA ...

RNA-Seq is certainly better way to find out novel transcripts or lncRNA, which can not be captured on micro arrays. however, if you are ...

Long Non-Coding RNAs: The Regulatory Mechanisms, Research ...

The use of databases plays an auxiliary role in studying the interactions of lncRNAs with DNA methylases and histone modification enzymes. Generally, the ...

Strategies to target long non-coding RNAs in cancer treatment

Specific expression of lncRNAs provides the possibility of killing cancer cells selectively. Their low expression allows the use of lncRNA ...