Human Axonal Survival of Motor Neuron

Human axonal survival of motor neuron (a-SMN) protein ... - PubMed

Abstract. Spinal muscular atrophy is a fatal genetic disease of motoneurons due to loss of full-length survival of motor neuron protein, the ...

Human Axonal Survival of Motor Neuron (a-SMN) Protein Stimulates ...

Human Axonal Survival of Motor Neuron (a-SMN) Protein Stimulates Axon Growth, Cell Motility, C-C Motif Ligand 2 (CCL2), and Insulin-like Growth ...

Axonal-SMN (a-SMN), a protein isoform of the survival motor neuron ...

We identified axonal-SMN (a-SMN), an alternatively spliced SMN form, preferentially encoded by the SMN1 gene in humans.

Survival of Motor Neuron - an overview | ScienceDirect Topics

The importance of SMN in humans was first realized when deletions or mutations in the SMN1 gene were found to cause Spinal Muscular Atrophy (SMA), the leading ...

Survival motor neuron (SMN) protein: role in neurite outgrowth and ...

Taken together, these results suggest that SMN may indeed fulfill neuronal- and muscle-specific functions, providing a more plausible mechanism explaining motor ...

The Survival of Motor Neuron Protein Acts as a Molecular ...

Interaction of survival of motor neuron (SMN) and HuD proteins with mRNA cpg15 rescues motor neuron axonal deficits ... The human centromeric survival motor ...

Survival of Motor Neuron - an overview | ScienceDirect Topics

In SMA, the breakdown of the NMJ and axon degeneration precede the death of spinal motor neurons. The muscle target plays a crucial role in the number and ...

PTEN depletion rescues axonal growth defect and improves survival ...

2C) (P < 0.001, n = 4 independent experiments). To assess the effects of RNAi treatment on axonal growth, motor neurons were fixed after 7 days in culture and ...

Survival Motor Neuron Protein in Motor Neurons Determines ...

Importantly, SMN also appears to function in muscle growth and/or maintenance independent of motor neurons. Our data suggest that SMN plays ...

Interaction of survival of motor neuron (SMN) and HuD proteins with ...

29). In brief, motor axons innervating the mid-trunk (myotomes 7–16) were examined under the compound microscope. Normal motor axon morphology ...

Decay in survival motor neuron and plastin 3 levels during ... - Nature

Spinal muscular atrophy (SMA) is a neuromuscular disease caused by mutations in Survival Motor Neuron 1 (SMN1), leading to degeneration of ...

Enhanced axonal regeneration of ALS patient iPSC-derived motor ...

Neurons and other brain cell types differentiated from human induced pluripotent stem cells (hiPSCs) have been valuable tools for understanding ...

The role of survival motor neuron protein (SMN) in protein ...

The survival motor neuron (SMN) protein was first highlighted as a protein of interest when mutations in its coding gene, SMN1, were linked to ...

Knockdown of the survival motor neuron (Smn) protein in zebrafish ...

Defects were rarely seen in the proximal axon extending from the spinal cord to the first intermediate target, suggesting that initiation of axon outgrowth and ...

Screening for axon regeneration promoting compounds with human ...

Although sensory and motor neuron axons do regrow after peripheral nerve injury, functional outcome is limited due to the incomplete and slow ...

Reduced Survival of Motor Neuron (SMN) Protein in Motor Neuronal ...

We conclude that selective knock-down of SMN in motor neurons is sufficient but may not be necessary to cause a disease phenotype.

Human Axonal Survival of Motor Neuron (a-SMN) Protein Stimulates ...

Human Axonal Survival of Motor Neuron (a-SMN) Protein Stimulates Axon Growth, Cell Motility, C-C Motif Ligand 2 (CCL2), and Insulin-like Growth Factor-1 (IGF1) ...

Dynamics of Survival of Motor Neuron (SMN) Protein Interaction with ...

Furthermore, we have previously demonstrated that low levels of SMN severely impair the axonal localization of polyA mRNAs in motor neurons. ( ...

(PDF) Axonal-SMN (a-SMN), a protein isoform of the survival motor ...

In the spinal cord, the a-SMN protein is selectively expressed in motor neurons and mainly localized in axons. Forced expression of a-SMN stimulates motor ...

Axon Biology in ALS: Mechanisms of Axon Degeneration and ...

Nerve injury studies show that adult motor and sensory neurons in lumbar spinal cord both survive loss of their distal axons, which is important ...