Human IFNAR2 deficiency

Human IFNAR2 deficiency: lessons for antiviral immunity - PMC

Human IFNAR2 deficiency causes fatal susceptibility to live viral vaccines, revealing a vital but narrow nonredundant role for IFN-α/β in viral ...

Human IFNAR2 deficiency: Lessons for antiviral immunity - PubMed

Type I interferon (IFN-α/β) is a fundamental antiviral defense mechanism. Mouse models have been pivotal to understanding the role of ...

Human IFNAR2 deficiency: Lessons for antiviral immunity - Science

The previously healthy proband developed fatal encephalitis after exposure to the live attenuated measles, mumps, and rubella vaccine.

Life-threatening viral disease in a novel form of autosomal recessive ...

, et al. 2015 . Human IFNAR2 deficiency: Lessons for antiviral immunity . Sci. Transl. Med. 7. : 307ra154 . https://doi.org/10.1126 ...

IFNAR2 Deficiency Causing Dysregulation of NK Cell Functions and ...

A large body of evidence demonstrates the pivotal role of interferon (IFN)-γ in the pathogenesis of both primary and secondary HLH forms (Jordan ...

Genetic Lesions of Type I Interferon Signalling in Human Antiviral ...

... human IFNAR1 and IFNAR2 deficiency appeared to be indistinguishable. ... Human IFNAR2 deficiency: lessons for antiviral immunity. Sci. Transl ...

IFNAR2 relevance in the clinical outcome of individuals with severe ...

Human IFNAR2 deficiency: lessons for antiviralimmunity. Sci Transl Med (2015) 7:307ra154. doi: 10.1126/SCITRANSLMED.AAC4227. PubMed Abstract ...

IFNAR2 - an overview | ScienceDirect Topics

... human IFNAR1 and IFNAR2 deficiency appeared to be indistinguishable. Responses to IFNγ were intact in both IFNAR1- and IFNAR-deficient fibroblasts in vitro ...

Human IFNAR2 deficiency: Lessons for antiviral immunity.

This human study identified that autosomal recessive mutations in IFNAR2 cause a defect in antiviral immunity that confers selective ...

Null IFNAR1 and IFNAR2 alleles are surprisingly common in the ...

... human individuals with inborn errors of type I ... patients from three unrelated kindreds for AR complete IFNAR2 deficiency, respectively.

Interferon-α/β–Receptor-2 Deficiency Leading to Multiple Infections ...

Human IFNAR2 deficiency: lessons for antiviral immunity. Sci Transl Med. 2015;7:307ra154. Passarelli C, Civino A, Rossi MN, et al. IFNAR2 ...

Human IFNAR2 deficiency: Lessons for antiviral immunity

The phenotype of IFNAR2 deficiency, together with similar findings in STAT2-deficient patients, supports an essential but narrow role for IFN-α/β in human ...

Human inherited complete STAT2 deficiency underlies inflammatory ...

Seven children with IFNAR1 deficiency and 5 with IFNAR2 deficiency displayed severe disease after LAVs and natural viral infections (32–34).

cases of interferon-alpha/beta receptor 2 deficiency

However, IFNs are known to contribute to the activation of innate and adaptive immune responses. Human Interferon-alpha/beta receptor 2 (IFNAR2) deficiency ...

Human IFNAR2 deficiency : lessons for antiviral immunity

The phenotype of IFNAR2 deficiency, together with similar findings in STAT2-deficient patients, supports an essential but narrow role for IFN-α/β in human ...

Human IFNAR2 deficiency: Lessons for antiviral immunity

The phenotype of IFNAR2 deficiency, together with similar findings in STAT2-deficient patients, supports an essential but narrow role for IFN- α ...

Human IFNAR2 deficiency: lessons for antiviral immunity - ePrints

Human IFNAR2 deficiency: lessons for antiviral immunity. Lookup NU author(s): Dr Christopher DuncanORCiD, Dr Siti Mohamad, Professor Andrew Cant, Dr Karin ...

Human IFNAR2 deficiency : lessons for antiviral immunity

The phenotype of IFNAR2 deficiency, together with similar findings in STAT2-deficient patients, supports an essential but narrow role for IFN-α/ ...

Human STAT2 deficiency: a severe defect of antiviral immunity

The type I IFN receptor (IFNAR) is a ubiquitously expressed heterodimer composed of IFNAR1 and IFNAR2. The type III IFN receptor (IFNLR) is also ...

INTERFERON-ALPHA, -BETA, AND -OMEGA RECEPTOR 2; IFNAR2

Human IFNAR2 deficiency: lessons for antiviral immunity. Sci. Transl. Med. 7: 307ra154, 2015. Note: Electronic Article. [PubMed: 26424569, images, related ...