Human Mitochondrial RNA Processing and Modifications

Human Mitochondrial RNA Processing and Modifications: Overview

Mitochondria, often referred to as the powerhouses of cells, are vital organelles that are present in almost all eukaryotic organisms, ...

Human Mitochondrial RNA Processing and Modifications: Overview

The present review discusses the current state of knowledge of RNA processing in human mitochondria and sheds some light on the unresolved issues.

Mitochondrial RNA modifications shape metabolic plasticity ... - Nature

The function of these RNA modifications is to determine the accuracy and optimal rate of translation. The mitochondrial protein synthesis ...

Structural basis of RNA processing by human mitochondrial RNase P

In humans, mtDNA is transcribed by a mitochondrial RNA polymerase (mtRNAP), which produces polycistronic primary transcripts that contain ...

Full article: Mitochondrial RNA maturation - Taylor & Francis Online

The production of functional mitochondrial RNA across species evolved in many directions. Organelles use a dizzying array of RNA processing, ...

The emergent role of mitochondrial RNA modifications in metabolic ...

Mitochondrial-RNA modifications represent an important pathway in the regulation of important gene expression in the context of the ...

Mitochondrial RNA - an overview | ScienceDirect Topics

Mitochondrial RNAs are produced from polycistronic transcripts and undergo processing and modification to produce mature mRNA (polyadenylation), rRNA ( ...

The Human Mitochondrial Transcriptome - Cell Press

This integrated analysis of the mitochondrial transcriptome reveals unexpected complexity in the regulation, expression, and processing of mitochondrial RNA and ...

The human mitochondrial mRNA structurome reveals mechanisms ...

Over the past five decades, the molecular machineries and mechanisms governing mtDNA transcription and mitochondrial messenger RNA (mt-mRNA) ...

How RNAs are made-to-measure to power our cells - mpinat

... RNA processing in human mitochondria. Their findings reveal for the first time how mitochondrial RNAs are cut, and explain why mutations in ...

molecular machinery for maturation of primary mtDNA transcripts

The first step of mitochondrial RNA processing consists of the separation of primary transcripts into individual, functional RNA molecules and can occur by two ...

Identification of human mitochondrial RNA cleavage sites and ...

but are more likely to be triggering changes in mitochon- drial RNA processing through intermediate mechanisms. The remaining eight are strong candidates ...

Human Mitochondrial RNA Processing and Modifications: Overview

Abnormalities occurring in mitochondria, such as mitochondrial DNA (mtDNA) mutations and disturbances at any stage of mitochondrial RNA (mtRNA) processing and ...

Mitochondria: Mitochondrial RNA metabolism and human disease

Mutations in these nuclear genes can lead to perturbations in mitochondrial RNA processing, modification, stability and decay and thus are a cause of human ...

The mitochondrial epitranscriptome: the roles of RNA modifications ...

RNA modifications in the mammalian mitochondrial translation apparatus play key roles in facilitating mitochondrial gene expression.

Human Mitochondrial RNA Processing and Modifications: Overview

Abnormalities occurring in mitochondria, such as mitochondrial DNA (mtDNA) mutations and disturbances at any stage of mitochondrial RNA (mtRNA) processing and ...

The FASTK family proteins fine-tune mitochondrial RNA processing

The human mitochondrial transcription generates long polycistronic transcripts that carry information for multiple genes, so that the expression level of each ...

RNA processing in human mitochondria - Semantic Scholar

... processing of tRNAs. Finally, we found that MRPP1 is essential for transcript processing, RNA modification, translation and mitochondrial respiration.

Nuclear genetic regulation of human mitochondrial RNA modification

Here, we quantify variation in RNA modification levels at functionally important positions in the mitochondrial genome across 11,552 samples ...

Integrated genomic analysis of mitochondrial RNA processing in ...

The mitochondrial genome is transcribed as continuous polycistrons of RNA containing multiple genes. As a consequence, post-transcriptional ...