Human Pluripotent Stem Cell–Derived TSC2|Haploinsufficient ...

Human Pluripotent Stem Cell-Derived TSC2-Haploinsufficient ...

Lymphangioleiomyomatosis (LAM) is a progressive destructive neoplasm of the lung associated with inactivating mutations in the TSC1 or TSC2 ...

Human pluripotent stem cell-derived TSC2-haploinsufficient smooth ...

These patient-derived cells carry a parental germline TSC2 mutation and express reduced levels of TSC2. They are expandable in culture, and ...

Human Pluripotent Stem Cell–Derived TSC2-Haploinsufficient ...

The patient iPSC-derived stem cell–based model described in this study will illuminate pathophysiology and therapeutic possibilities in ...

(PDF) Human Pluripotent Stem Cell-Derived TSC2-Haploinsufficient ...

ArticlePDF Available. Human Pluripotent Stem Cell-Derived TSC2-Haploinsufficient Smooth Muscle Cells Recapitulate Features of ...

2018 Tuberous Sclerosis Complex Highlight - Modeling TSC and ...

Modeling TSC and LAM Using Patient-Derived Induced Pluripotent Stem Cells ... Human pluripotent stem cell-derived TSC2-haploinsufficient smooth ...

Human pluripotent stem cell modeling of tuberous sclerosis complex ...

A recent TSC patient-derived smooth muscle cell model recapitulates important aspects of LAM cells (Julian et al., 2017), yet the impact of TSC2 ...

Establishment of human induced pluripotent stem cell lines ...

The peripheral blood mononuclear cells (PBMCs) from a patient carrying mosaic nonsense mutation of TSC2 gene were reprogrammed using the CytoTune-iPS2.0 Sendai ...

Human Pluripotent Stem Cell–Derived TSC2 - OUCI

Human Pluripotent Stem Cell–Derived TSC2-Haploinsufficient Smooth Muscle Cells Recapitulate Features of Lymphangioleiomyomatosis · Lisa M. Julian · Sean P.

Recent advances in human stem cell-based modeling of Tuberous ...

Genetically engineered human embryonic stem cells [29], TSC patient-derived ... pluripotent stem cells partially mimicked development of TSC2 ...

New frontiers in modeling tuberous sclerosis with human stem cell ...

... cell-derived ... Abnormal Neural Progenitor Cells Differentiated from Induced Pluripotent Stem Cells Partially Mimicked Development of TSC2 ...

Impact of TSC2-deficient neural cells on microglial structure and ...

... human pluripotent stem cell-derived microglia and TSC2 mutant neural cells. Our results will finally elucidate the role of microglia in CTs, a critical ...

Article Abnormal Neural Progenitor Cells Differentiated from Induced ...

However, a recent study on neurons derived from TSC2-deleted pluripotent stem cells demonstrated that heterozygous and homozygous loss of TSC2 ...

The generation and characterization of a human induced pluripotent ...

... derived induced pluripotent stem cells (iPSCs) to investigate TSC cellular and molecular phenotypes. In these cell lines we observe that TSC2 +/ NPCs ...

Stem Cell Reports

To study the involvement of neuron-glia interactions in TSC phenotypes, we generated TSC patient induced pluripotent stem cell (iPSC)-derived ...

Genomic analysis of the molecular neuropathology of tuberous ...

Two TSC2-deficient cell lines were derived from a parental stem cell ... stem cells, glia and neurons derived from human pluripotent stem cells.

New frontiers in modeling Tuberous Sclerosis with human stem cell ...

... TSC2; mTOR; cortical tuber; human pluripotent stem cells; brain organoids ... stem cell derived-neurons and brain organoids to investigate disease mechanisms in ...

Modeling Rare Human Tuberous Sclerosis Complex-Associated...

TSC2 -/- hiPSC-derived AML organoid xenografts recapitulate key features of human TSC ... Derived Human-Induced Pluripotent Stem Cells.

Establishment of Tsc2‑deficient rat embryonic stem cells

... Tsc2−/− cells in chimeras induced embryonic lethality. Further ... Embryonic stem cell lines derived from human blastocysts. Science ...

New frontiers in modeling tuberous sclerosis with human stem cellâ

... Cells. Differentiated from Induced Pluripotent Stem Cells Partially. Mimicked Development of TSC2 Neurological Abnormalities. Stem Cell Reports.

Patient-derived TSC2 loss of function mutant induced pluripotent ...

Download scientific diagram | Patient-derived TSC2 loss of function mutant induced pluripotent stem cell cultures have multipolar mitotic cells.