Human immune diversity

Human immune diversity: from evolution to modernity - Nature

The extreme diversity of the human immune system, forged and maintained throughout evolutionary history, provides a potent defense against ...

Human immune diversity: from evolution to modernity - PubMed

The extreme diversity of the human immune system, forged and maintained throughout evolutionary history, provides a potent defense against ...

Shaping Variation in the Human Immune System - Cell Press

Diversity within the human immune system is stable over the duration of months to years with an elastic response to immunological challenge, allowing the study ...

The influence of natural selection on population immune diversity ...

Here, we discuss the role that natural selection has played in driving phenotypic differences in immune responses across populations.

The generation of diversity in immunoglobulins - NCBI

The total number of antibody specificities available to an individual is known as the antibody repertoire, or immunoglobulin repertoire, and in humans is at ...

Giant project will chart human immune diversity to improve drugs ...

The effort will probe thousands of immune variables in blood and tissue samples. The result will likely be the world's largest and most comprehensive ...

Commonality despite exceptional diversity in the baseline human ...

The diversity of the naive antibody repertoire in humans is estimated to be at least 1012 unique antibodies. Because the number of peripheral ...

Human Immunology through the Lens of Evolutionary Genetics

In particular, there is growing evidence confirming that the diversity of immune genes is driven by human exposure to pathogens. For example ...

Human immune diversity: from evolution to modernity - Ex Libris

The extreme diversity of the human immune system, forged and maintained throughout evolutionary history, provides a potent defense against opportunistic ...

Single-cell analysis of human diversity in circulating immune cells

Summary. Lack of diversity and proportionate representation in genomics datasets and databases contributes to inequity in healthcare outcomes ...

Immune Gene Diversity in Archaic and Present-day Humans

In both archaic and present-day humans, genes with the highest levels of diversity are enriched for MHC-related functions. In fact, in archaic ...

Challenges of Immune Response Diversity in the Human Population ...

We discuss the impact of human genetic variations on immune responses and how they relate to failures seen in current TB diagnostic, therapy, and vaccine ...

Diversity of antibodies - Kyowa Kirin

This is called the “diversity” of an antibody. The diversity of antibodies is created by the combination of variable regions of H chains and L chains. It is ...

Human Immune Health Atlas - Allen Institute

The atlas provides detailed profiles of 71 distinct immune cell subsets, based on the analysis of 1.8 million cells taken from over 100 healthy ...

Shaping Variation in the Human Immune System - ScienceDirect.com

Genetic approaches have identified genetic diversity as drivers of 20⿿40% of the variation between the immune systems of individuals. The remaining 60⿿80% is ...

Scientific Approach - Human Immunome Project

As a result, immunologists estimate that less than 1% of the data required to understand global immune function and diversity are available. These gaps prevent ...

Shaping Variation in the Human Immune System - Cell Press

Genetic approaches have identified genetic diversity as drivers of 20⿿40% of the variation between the immune systems of individuals. The remaining 60⿿80% is ...

Human immune diversity: from evolution to modernity. - Europe PMC

Abstract. The extreme diversity of the human immune system, forged and maintained throughout evolutionary history, provides a potent defense against ...

Immune system - Lymphocytes, Diversity, Adaptive | Britannica

Since the entire human genome contains approximately 25,000 genes, individuals cannot inherit a gene for each particular antigen receptor ...

Continuous immunotypes describe human immune variation ... - PNAS

Our analyses of various measured immune cell population frequencies in healthy humans and their responses to diverse stimuli show that human immune variation is ...