Human liver chimeric mice provide a model for hepatitis B ...

Human liver chimeric mice provide a model for hepatitis B ... - PubMed

A paucity of versatile small animal models of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection has been an impediment to both furthering ...

Human liver chimeric mice provide a model for hepatitis B and C ...

Our study reveals that even minimally repopulated chimeric mice (human serum albumin, 0.04–0.16 mg/ml) can be productively infected by HBV, ...

Human liver chimeric mice provide a model for hepatitis B and ... - JCI

Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment ... Citation Information: J Clin Invest. 2010;120(3) ...

Humanized chimeric mouse models of hepatitis B virus infection

The A2/NSG-hu-HSC/Hep mouse model also enables the development of a human immune system and maintenance of human liver cells after the injection of CD34+ HSCs ...

A Chimeric Humanized Mouse Model by Engrafting the ... - Frontiers

The first line cells used for HBV infection has been the primary human hepatocytes (PHHs). After PHHs were engrafted in the liver of an immune-deficient mouse, ...

Liver chimeric mice with tupaia hepatocyte transplantation as an ...

The human liver chimeric mouse is a milestone animal model for hepatitis B virus (HBV) infection. Such mice with primary human hepatocyte (PHH) transplantation ...

Chimeric mouse model of hepatitis B virus infection

(4) While mouse hepatocytes do not support HBV infection, human-chimeric mice can be efficiently infected by injecting infectious serum derived from either ...

Human liver chimeric mice provide a model for hepatitis B and C ...

This human liver chimeric mouse model will expand the experimental possibilities for studying HBV and HCV infection, and possibly other human ...

Liver-humanized mice to study hepatis B virus infection

A new study published in Microbiology Spectrum reports the establishment of a liver-humanized NSG-PiZ mouse model that is fully permissive to hepatitis B virus ...

In Vivo Mouse Models for Hepatitis B Virus Infection and Their ...

However, these mouse models have great limitations as no spread of HBV infection occurs in the mouse liver and no or only very mild hepatitis is present. Thus, ...

Combinatorial RNA Interference Therapy Prevents Selection of Pre ...

Human liver chimeric mice were infected with a mixture of wild-type and T472C HBV, a S1-resistant HBV variant and then treated with a single or ...

Animal Models for Hepatitis B: Does the Supply Meet the Demand?

Without an established small animal model that supports the entire life cycle of HBV and recapitulates human disease phenotypes, our ability to ...

Mouse Models of Hepatitis B Virus Infection Comprising Host ... - MDPI

These two types of human hepatocyte chimeric mice are susceptible to HBV infections (see Figure 3) [53,54,55]. The establishment of HBV infection is generally ...

Chimeric Mouse Model for the Infection of Hepatitis B and C Viruses

These transgenic mice are healthy relative to Alb-uPA mice and provide a long window from about age 4 to 12 months for engraftment with human hepatocytes.

Optimized HepaRG is a suitable cell source to generate the human ...

The human liver chimeric mouse with primary human hepatocytes (PHHs) engraftment has been demonstrated to be a useful animal model to study hepatitis B ...

Mouse models for therapeutic vaccination against hepatitis B virus

Mice with livers efficiently repopulated with human hepatocytes [31] become susceptible for HBV infection and allow the formation of HBV cccDNA.

Animal Models of Hepatitis B Virus Infection–Success, Challenges ...

An increased understanding of the barriers towards interspecies transmission has aided in the development of human chimeric mice and has greatly paved the way ...

Hepatitis C virus replication in mice with chimeric human livers

Lack of a small animal model of the human hepatitis C virus (HCV) has impeded development of antiviral therapies against this epidemic infection.

Human liver chimeric mice provide a model for hepatitis B and C ...

Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment ... Bissig KD, Wieland SF, Tran P, Isogawa M, Le TT, ...

Humanized Liver Mouse Models for Translational Preclinical Research

PXB-mice have up to 95% human hepatocyte engraftment in the liver, and express stable blood levels of human albumin, a biomarker of humanization, over their ...