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Hyaluronan synthase


Hyaluronan synthase - Wikipedia

Hyaluronan synthase ... Hyaluronan synthases (HAS) are membrane-bound enzymes that use UDP-α-N-acetyl-D-glucosamine and UDP-α-D-glucuronate as substrates to ...

Hyaluronan Synthase - an overview | ScienceDirect Topics

Hyaluronan Synthase ... Hyaluronan Synthase is a glycosyltransferase enzyme located on the plasma membrane, responsible for synthesizing hyaluronan by adding ...

Structure, substrate recognition and initiation of hyaluronan synthase

Hyaluronan is an acidic heteropolysaccharide comprising alternating N-acetylglucosamine and glucuronic acid sugars that is ubiquitously ...

Hyaluronan Synthase 1: A Mysterious Enzyme with Unexpected ...

Abstract. Hyaluronan synthase 1 (HAS1) is one of three isoenzymes responsible for cellular hyaluronan synthesis. Interest in HAS1 has been ...

Hyaluronan Synthase - an overview | ScienceDirect Topics

Hyaluronan synthases are the types of the transmembrane glycosyltransferase isoenzymes that carry out the cellular synthesis of HA in the human body. There are ...

3036 - Gene ResultHAS1 hyaluronan synthase 1 [ (human)] - NCBI

Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from ...

Hyaluronan synthases; mechanisms, myths, & mysteries of three ...

This review discusses current understanding of HA biosynthesis, its biotechnological utility, and addresses some misconceptions in the literature.

Dissecting the role of sub structural elements of hyaluronan synthase

Hyaluronic acid (HA) based biomaterials have several biomedical applications. HA biosynthesis is catalysed by hyaluronan synthase (HAS).

Hyaluronan synthases; mechanisms, myths, & mysteries of three ...

Hyaluronan (hyaluronic acid, hyaluronate, HA) is an essential polysaccharide in the extracellular matrix of mammals and found in all chordates ...

Recombinant P. multocida Hyaluronan Synthase/HAS Protein, CF

P. multocida Hyaluronan Synthase protein (9585-GT) is manufactured by R&D Systems, over 95% purity. Reproducible results in enzyme activity assays.

Elevated expression of hyaluronan synthase 2 associates with ...

This study indicates that elevated expression of HAS2 is associated with glioma progression and suggests that HAS2 has a prognostic significance in diffusely ...

hyaD - Hyaluronan synthase - Pasteurella multocida | UniProtKB

Catalyzes the polymerization of hyaluronan, a polysaccharide composed of a repeating disaccharide of N-acetylglucosamine (GlcNAc) and glucuronic acid ...

HAS2 - Wikipedia

Hyaluronan synthase 2 is an enzyme that in humans is encoded by the HAS2 gene. HAS2. Identifiers. Aliases · HAS2, hyaluronan synthase 2.

Hyaluronan Synthase: The Mechanism of Initiation at the Reducing ...

We review here the evidence for a synthase pore-mediated polysaccharide translocation process and describe a possible mechanism (the Pendulum Model)

Hyaluronan Synthase 1-3 (HAS1-3) - SpringerLink

HAS is a glycosyltransferase enzyme that polymerizes HA. HAS activity was characterized for the first time in the group A streptococcus bacterium.

HAS2 (hyaluronan synthase 2)

HAS2 is one of the three characterized HA synthases responsible for the polymerization of Hyaluronic Acid in the extracellular matrix and is the ...

Hyaluronan Synthases* - Journal of Biological Chemistry

In this report, we describe recent advances that provide exciting new insights into the biosynthetic side of these metabolic processes.

Hyaluronan synthase (PmHAS) - Chemily Glycoscience

Hyaluronan synthase (PmHAS) ... Unit Define: PmHAS polymerizes Hyaluronan chain from UDP-GlcNAc and UDP-GlcA sugar nucleotide donors. ... The product is already in ...

HAS3 - Hyaluronan synthase 3 - Homo sapiens (Human) - UniProt

Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major ...

A Connecting Link between Hyaluronan Synthase 3-Mediated ...

Hyaluronan (HA), an essential component of the extracellular matrix of the skin, is synthesized by HA synthases (HAS1-3). To date, epidermal HA has been ...