Hyaluronan synthases

Hyaluronan synthase ... Hyaluronan synthases (HAS) are membrane-bound enzymes that use UDP-α-N-acetyl-D-glucosamine and UDP-α-D-glucuronate as substrates to ...

Hyaluronan Synthase - an overview | ScienceDirect Topics

Hyaluronan Synthase ... Hyaluronan Synthase is a glycosyltransferase enzyme located on the plasma membrane, responsible for synthesizing hyaluronan by adding ...

Hyaluronan Synthase: The Mechanism of Initiation at the Reducing ...

We review here the evidence for a synthase pore-mediated polysaccharide translocation process and describe a possible mechanism (the Pendulum Model)

Hyaluronan Synthase - an overview | ScienceDirect Topics

Hyaluronan synthases are the types of the transmembrane glycosyltransferase isoenzymes that carry out the cellular synthesis of HA in the human body. There are ...

Structure, substrate recognition and initiation of hyaluronan synthase

Hyaluronan is an acidic heteropolysaccharide comprising alternating N-acetylglucosamine and glucuronic acid sugars that is ubiquitously ...

Hyaluronan Synthase 1: A Mysterious Enzyme with Unexpected ...

Abstract. Hyaluronan synthase 1 (HAS1) is one of three isoenzymes responsible for cellular hyaluronan synthesis. Interest in HAS1 has been ...

Hyaluronan synthases; mechanisms, myths, & mysteries of three ...

This review discusses current understanding of HA biosynthesis, its biotechnological utility, and addresses some misconceptions in the literature.

Hyaluronan Synthases* - Journal of Biological Chemistry

In this report, we describe recent advances that provide exciting new insights into the biosynthetic side of these metabolic processes.

Dissecting the role of sub structural elements of hyaluronan synthase

Hyaluronic acid (HA) based biomaterials have several biomedical applications. HA biosynthesis is catalysed by hyaluronan synthase (HAS).

Hyaluronan synthases; mechanisms, myths, & mysteries of three ...

Hyaluronan (hyaluronic acid, hyaluronate, HA) is an essential polysaccharide in the extracellular matrix of mammals and found in all chordates ...

Mammalian Hyaluronan Synthases - Itano - 2002 - IUBMB Life

Three mammalian hyaluronan (HA) synthase genes, HAS1, HAS2, and HAS3, have been cloned and expressed, allowing the mechanisms for regulation ...

Hyaluronan synthases: fascinating glycosyltransferases from ...

Hyaluronan (or hyaluronic acid or hyaluronate; HA) is a polysaccharide found in the extracellular matrix of vertebrate tissues and in the surface coating o.

Dissecting the role of hyaluronan synthases in the tumor ...

We will focus on the role of both high and low molecular weight hyaluronan in controlling the hallmarks of cancer cells, including cell proliferation, ...

Recombinant P. multocida Hyaluronan Synthase/HAS Protein, CF

P. multocida Hyaluronan Synthase protein (9585-GT) is manufactured by R&D Systems, over 95% purity. Reproducible results in enzyme activity assays.

Hyaluronan Synthases - OUHSC Profiles

HYALURONAN SYNTHASE 2 (HAS2) is essential for embryogenesis and its expression by tumor cells is associated with metastasis.

Elevated expression of hyaluronan synthase 2 associates with ...

This study indicates that elevated expression of HAS2 is associated with glioma progression and suggests that HAS2 has a prognostic significance in diffusely ...

Hyaluronan Synthase 1-3 (HAS1-3) - SpringerLink

HAS is a glycosyltransferase enzyme that polymerizes HA. HAS activity was characterized for the first time in the group A streptococcus bacterium.

Bacterial Hyaluronan Synthases -Update- - Glycoforum

As of 2004, >20 hyaluronan synthases have been identified and cloned, and many have been expressed as recombinant proteins.

Hyaluronan Synthases* - Journal of Biological Chemistry

They showed that this substance contained a hexuronic acid, an amino sugar, and no sulfoesters and proposed the name hyaluronic acid (hyaluronan, HA),1 from the ...

2.4.1.212: hyaluronan synthase - BRENDA Enzyme Database

2.4.1.212: hyaluronan synthase · Word Map on EC 2.4.1.212 Wordmap for 2.4.1.212. 2.4.1.212; glycosaminoglycans; collagen; polysaccharide; keratinocytes ...