Hydroxocobalamin in Refractory Septic Shock

Hydroxocobalamin in Refractory Septic Shock - PubMed Central

Refractory septic shock is associated with high morbidity and mortality. Hydroxocobalamin is used to treat postoperative vasoplegia; ...

Hydroxocobalamin in Refractory Vasodilatory Shock

Hydroxocobalamin increases blood pressure by a pathway not targeted by the mainstay vasopressor therapies used in vasodilatory shock, inhibiting ...

Is intravenous hydroxocobalamin an effective treatment for ...

While the use of hydroxocobalamin is hypothesized to help with shock-associated refractory vasoplegia, there are a limited number of studies testing this ...

Hydroxocobalamin in Refractory Septic Shock - PubMed

Hydroxocobalamin provides sustained hemodynamic benefit at 24 hours in patients with refractory septic shock.

Hydroxocobalamin for Vasodilatory Hypotension in Shock: A ...

Hydroxocobalamin inhibits nitric oxide-mediated vasodilation, and has been used in settings of refractory shock. However, its effectiveness and role in ...

Hydroxocobalamin for refractory septic shock

INTRODUCTION: Refractory septic shock is defined as circulatory failure despite the use of high-dose vasopressors and fluid resuscitation. Hydroxocobalamin ...

Hydroxocobalamin in Refractory Vasodilatory Shock

was septic shock, from which the inpatient mortality of patients requiring a trial of hydroxocobalamin was more than twice that in the cardiac surgery ...

Treatment of refractory shock with vitamin B 12 : A narrative review

High-dose vitamin B12 is a potential treatment for patients with vasodilatory shock that is refractory to other therapies.

ALL THAT AND A BAG OF B12 - CHEST Journal

support hydroxocobalamin's efficacy in improving MAP and reducing vasopressor requirements in refractory septic shock. ... (Vitamin B12) in Septic ...

(PDF) Hydroxocobalamin in Refractory Septic Shock - ResearchGate

Abstract and Figures. Refractory septic shock is associated with high morbidity and mortality. Hydroxocobalamin is used to treat postoperative ...

1257: Hydroxocobalamin for Refractory Septic Shock - LWW

Hydroxocobalamin is a nitric oxide scavenger that has seen limited use as a rescue therapy for patients with refractory septic shock. Our study aimed to ...

Is Hydroxocobalamin the New Vitamin C? A Budding Strategy to ...

With a promising mechanistic approach, hydroxocobalamin may be a budding strategy to manage refractory vasoreactivity and uncontrolled inflammation that ...

High-Dose IV Hydroxocobalamin (Vitamin B12) in Septic Shock: A ...

Elevated hydrogen sulfide (H2S) contributes to vasodilatation and hypotension in septic shock, and traditional therapies do not target this pathophysiologic ...

ALL THAT AND A BAG OF B12: FIVE PRESSOR REFRACTORY ...

INTRODUCTION: Hydroxocobalamin has been historically effective in vasoplegia during cardiac surgery. More recently, it has been used for septic shock. We ...

Hydroxocobalamin (Vitamin B12) for Septic Shock - eddyjoemd

What vitamin B12 SHOULD do in patients with septic shock is that it “scavenges and prevents NO and H2S formation and has the potential to recuse ...

Use of High-Dose Hydroxocobalamin for Septic Shock: A Case Report.

After the administration of high-dose hydroxocobalamin for presumed septic vasoplegic syndrome, both patients had an immediate response to hydroxocobalamin with ...

Hydroxocobalamin in Refractory Septic Shock - OUCI

Objectives: Refractory septic shock is associated with high morbidity and mortality. Hydroxocobalamin is used to treat postoperative vasoplegia; however, ...

High-Dose Hydroxocobalamin for Refractory Vasoplegia Post ...

Administration of high-dose hydroxocobalamin, or vitamin B12, is an emerging, targeted rescue therapy for the treatment of refractory ...

Approach to shock & refractory shock - EMCrit Project

Refractory septic shock (supported by a pilot trial showing reduced ... High-Dose IV Hydroxocobalamin (Vitamin B12) in Septic Shock: A ...

CAN ADMINISTRATION OF HIGH-DOSE HYDROXOCOBALAMIN ...

1244: CAN ADMINISTRATION OF HIGH-DOSE HYDROXOCOBALAMIN IMPROVE OUTCOMES IN REFRACTORY SEPTIC SHOCK? ... To read the full-text of this research, you can request a ...