IDH mutation in glioma

IDH mutation in glioma: molecular mechanisms and potential ...

Here we provide an overview of the latest findings in IDH-mutated human malignancies, with a focus on glioma, discussing unique biological signatures and ...

Mutant IDH in Gliomas: Role in Cancer and Treatment Options - PMC

Isocitrate dehydrogenase (IDH) is the most mutated metabolic gene in human cancer. Mutations in this gene have been identified in a high percentage of ...

Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro ...

Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions

Isocitrate dehydrogenase mutations in gliomas: A review of current ...

Glioma-associated IDH mutations disrupt these interactions and lead to reprogramming of central carbon metabolism. IDH1 and IDH2 mutations found in gliomas are ...

FDA Approves Drug for Low-Grade Glioma With IDH Gene Mutation

The US Food and Drug Administration (FDA) has now approved a new drug that slows the growth of low-grade diffuse gliomas with a certain gene mutation.

Isocitrate Dehydrogenase IDH1 and IDH2 Mutations in Human Cancer

IDH1 and IDH2 are often mutated in a tissue-specific manner, most commonly in gliomas. Mutation in both genes is linked to OS and PFS.

Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma

In a perioperative trial, vorasidenib therapy resulted in a reduction of more than 90% in the concentration of the oncometabolite 2- ...

New Clinical Trial Tests a Kind of Precision Medicine Treatment for ...

“Zotiraciclib is a kind of precision medicine for IDH-mutant gliomas,” Dr. Wu explains. Her previous phase 1 trialExit Disclaimer also showed ...

Treatment of IDH-mutant glioma in the INDIGO era - Nature

The recently published INDIGO trial, demonstrating the benefit of the mutant IDH inhibitor vorasidenib in patients with low-grade IDH-mutant ...

Understanding the Genetic Risk of IDH-Mutant Glioma

Understanding the Genetic Risk of IDH-Mutant Glioma. Authors: Tracy T. Batchelor, MD, MPH, and Kyle M. Walsh, Ph.D.

IDH1/2 Mutations in Glioma: ESMO Biomarker Factsheet

Mutations in the IDH1 and IDH2 genes have been identified in subsets of patients across a number of solid and haematologic malignancies.

Mutant IDH1 and seizures in patients with glioma - Neurology.org

We sought to determine whether IDH1 mut increases the risk of seizures in patients with glioma, and whether D2HG increases the electrical activity of neurons.

Vorasidenib Is Effective against Low-Grade Gliomas - NCI

Vorasidenib, a tablet that patients take by mouth, blocks the activity of abnormal IDH1 and IDH2 proteins in cancer cells, largely sparing ...

IDH Mutation in Glioma: New Insights and Promises for the Future

IDH mutation is an early event in gliomagenesis and has significant implications for glioma progression and tumor behavior.

How mutations in a single gene alter the course of a deadly brain ...

In contrast, median survival for patients with IDH-mutant gliomas can be five or even 10 years, depending on the specific tumor type. It turns ...

IDH Mutations in Glioma: Double-Edged Sword in Clinical ... - MDPI

Discovery of point mutations in the genes encoding isocitrate dehydrogenases (IDH) in gliomas about a decade ago has challenged our view of the role of ...

IDH mutations in glioma and acute myeloid leukemia - ScienceDirect

This review surveys the prevalence of IDH mutations in cancer and explores current mechanistic understanding of IDH mutations with implications for diagnostic ...

Therapies for IDH-Mutant Gliomas

This article provides an overview of IDH mutant gliomas, standard of care treatment, and novel therapeutic strategies.

Isocitrate dehydrogenase (IDH) | Radiology Reference Article

By definition, essentially all low-grade adult-type diffuse gliomas (astrocytomas and oligodendrogliomas) are IDH-mutant 12. It is important to ...

IDH Mutant Tumors Treatment for International Patients

IDH refers to isocitrate dehydrogenase (IDH) mutation brain tumors, including astrocytomas and oligodendrogliomas. The most common type of tumor originating in ...