IL|17A Orchestrates Reactive Oxygen Species/HIF1α|Mediated ...

IL-17A Orchestrates Reactive Oxygen Species/HIF1α-Mediated ...

Immune cell-derived IL-17A is one of the key pathogenic cytokines in psoriasis, an immunometabolic disorder. Although IL-17A is an ...

IL-17A Orchestrates Reactive Oxygen Species/HIF1α–Mediated ...

Supplementary data. Article Navigation. Research Article| November 29 2023 ... IL-17A Orchestrates Reactive Oxygen Species/HIF1α–Mediated Metabolic ...

IL-17A Orchestrates Reactive Oxygen Species/HIF1α-Mediated ...

Keratinocytes are identified as important target cells of IL-17A and its involvement in multiple downstream metabolic reprogramming pathways in human skin ...

IL-17A Orchestrates Reactive Oxygen Species/HIF1α–Mediated ...

Pharmacological inhibition of HIF1α or reactive oxygen species reversed IL-17A–mediated glycolysis, glutaminolysis, lipid uptake, and HPK hyperproliferation.

Volume 212 Issue 2 | The Journal of Immunology

IL-17A Orchestrates Reactive Oxygen Species/HIF1α–Mediated Metabolic Reprogramming in Psoriasis · Bhavuk Dhamija; Soumitra Marathe; Vinanti ...

HIF1A hypoxia inducible factor 1 subunit alpha [ (human)] - NCBI

Analysis of HIF-1alpha expression and genetic polymorphisms in human clear cell renal cell carcinoma. IL-17A Orchestrates Reactive Oxygen Species/HIF1alpha- ...

IL-17 and IL-17-producing cells in protection versus pathology - Nature

... mediate fungal clearance through the production of reactive oxygen species. IL-17 can also modulate protective TH1 cell responses and ...

IIT Bombay Proteomics - IL-17A Keratinocyte - PanoramaWeb

IL-17A Orchestrates Reactive Oxygen Species/HIF1α-Mediated Metabolic Reprogramming in Psoriasis. J Immunol. 2024 Jan 15;212(2):302-316. doi ...

HIF1α–dependent glycolytic pathway orchestrates a metabolic ...

The reliance on glycolysis (even in the presence of high levels of oxygen) to generate ATP, which is far less efficient than oxidative ...

High Glucose Intake Exacerbates Autoimmunity through Reactive ...

High Glucose Intake Exacerbates Autoimmunity through Reactive-Oxygen-Species-Mediated TGF-β Cytokine Activation ... ROS · autoimmune diseases ...

Hypoxia, oxidative stress, and the interplay of HIFs and NRF2 ...

... reactive oxygen species (ROS) levels. Under these conditions, cells ... ROS-independent ER stress-mediated NRF2 activation promotes ...

Reactive oxygen species formation and its effect on CD4+ T cell ...

When the feedback loop in activated T cells is disrupted, reduced IL-12 secretion decreases that of IFN-γ and T-bet, thereby affecting the Th1 cell-mediated ...

Reactive oxygen species trigger inflammasome activation after ...

In addition to pro-IL-1β cleavage, the inflammasome is responsible for IL-18 cleavage and pyroptosis, a type of inflammation-mediated cell death ...

Metabolic Reprogramming and Reactive Oxygen Species in T Cell ...

As critical host-mediated immune cells, T cells must be rapidly responded to foreign substances and efficiently proliferate in a timely manner.

Naringenin Orchestrates and Regulates the Reactive Oxygen ...

... oxidative stress and inflammatory response. The study aims at highlighting the reactive oxygen species-mediated activity of naringenin and the underlying ...

ILC3s integrate glycolysis and mitochondrial production of reactive ...

... reactive oxygen species (mROS) support alternative T reg cell differentiation. ... HIF1α orchestrates glycolysis (Düvel et al., 2010) and ...

Roles of reactive oxygen species in inflammation and cancer - Yu

However, under specific conditions, these species assume pivotal biological roles within cellular signaling pathways. ROS orchestrates crucial ...

Reactive oxygen species in cell signaling

Expression of collagenase by IL-1 may be mediated by an autocrine loop involving Rac1, ROS, and NF-κB in fibroblasts (136). IL-1 may inhibit fibrinolysis and ...

Reactive Oxygen Species in Inflammation and Tissue Injury

Mitochondrial-derived ROS (MtROS) also contributes to LPS-mediated production of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α (48). Notably, MtROS have ...

The PRAK-NRF2 axis promotes the differentiation of Th17 cells by ...

PRAK-Regulated Reactive Oxygen Species (ROS) Elimination Contributes to Th17 Cell Differentiation. Our previous work shown that Prak deficiency ...