IL|7 Enhances the Survival and Maintains the Size of Naive T Cells

IL-7 enhances the survival and maintains the size of naive T cells

IL-7 was found to maintain both the size and survival of neglected T cells in vitro. IL-7 was not unique, because the common gamma-chain cytokines IL-2, IL-4, ...

IL-7 Enhances the Survival and Maintains the Size of Naive T Cells1

IL-7 is a cytokine that provides a survival-promoting extrinsic signal to both T cells and B cells and has been shown to be critical for lymphocyte homeostasis ...

IL-7 Enhances the Survival and Maintains the Size of Naive T Cells

However, caspase activation is not required for death by the intrinsic pathway, be- cause alterations in cellular physiology when extrinsic signals are removed ...

IL-7 Promotes the Transition of CD4 Effectors to Persistent Memory ...

These cytokines can maintain the survival of resting naive T cells (17–21). On the other hand, activated CD4 and CD8 T cells, such as effector cells, and ...

Mutually exclusive regulation of T cell survival by IL-7R and antigen ...

Addition of IL-7 enhanced survival of unstimulated but not TCR-stimulated T ... survival to maintain homeostasis of naive T cells. For full ...

Interleukin-7 Biology and Its Effects on Immune Cells - Frontiers

... 7 promotes survival of both naïve and memory T cells (6). IL-7 was suggested ... IL-7 Enhances the Survival and Maintains the Size of Naive T Cells. J ...

In Vitro Effects on Naive T-Cell Population - ScienceDirect

... to other observations indicating that IL-7 maintains naive T-cell survival. ... Gao, et al. IL-7 enhances the survival and maintains the size of naive T cells.

Interleukin 7 Regulates the Survival and Generation of Memory CD4 ...

IL-7 enhances the survival and maintains the size of naive T cells. J. Immunol. 167. : 6869. –6876. Crossref · Search ADS · PubMed. 33. Peschon ...

Harnessing the Power of IL-7 to Boost T Cell Immunity in ...

... promotes the survival of both naïve and memory T cells. Thus, IL-7 is also essential for the functional fitness of T cells. In this regard ...

IL-7-Induced Glycerol Transport and TAG Synthesis ... - Cell Press

35. Rathmell, J.C. ∙ Farkash, E.A. ∙ Gao, W. ... IL-7 enhances the survival and maintains the size of naive T cells. J. Immunol. 2001; 167 ...

Transgenic expression of IL-7 regulates CAR-T cell metabolism and ...

We generated CAR-T cells armored with IL-7 to prolong the persistence of infused T-cells, particularly CD4 + T cells, and enhanced anti-tumor response.

IL-7: A promising adjuvant ensuring effective T cell responses and ...

Several studies have revealed that IL-7 improves the long-term immune responses against pathogens by inducing naïve T cells to memory T cells (57, 58). A high ...

IL-7Rα on CD4+ T cells is required for their survival and the ...

IL-7 enhances the survival and maintains the size of naive T cells. ... Interleukin-7 promotes the survival of human CD4 + effector/memory T cells ...

IL‐7 promotes the survival and maturation but not differentiation of ...

IL-7 maintained the naive T cells in a quiescent state expressing the CD45RA antigen. A significant finding was the loss of CD38 antigen expression on the naive ...

Step-dose IL-7 treatment promotes systemic expansion of T cells ...

IL-7 increased proliferation and survival of T cells and triggered several chemokines and cytokines. Induction of CXCL13 in lymph nodes (LNs) ...

Basal NF-κB controls IL-7 responsiveness of quiescent naïve T cells

... to maintain IL-7R expression in T cells and for their survival. Our results imply that antiinflammatory therapies targeting NF-κB may affect the pool of ...

IL-7 and IL-15 instruct the generation of human memory stem T cells ...

Key Points. Identification of the biologic requirements for memory stem T cell (TSCM) generation and expansion from naive precursors ex vivo ...

Seeing Is Believing: Illuminating the Source of In Vivo Interleukin-7

IL-7 enhances the survival and maintains the size of naive T cells. J Immunol 2001;167:6869–6876. PubMed · CrossRef. Surh CD, Sprent J ...

IL-7–dependent STAT1 activation limits homeostatic CD4 + T cell ...

IL-7 regulates homeostatic mechanisms that maintain the overall size of the T cell pool throughout life. We show that, under steady-state ...

IL-7 promotes Glut1 trafficking and glucose uptake via STAT5 ...

IL-7 enhances the survival and maintains the size of naive T cells. ... 7 is critical for homeostatic proliferation and survival of naive T cells ...