IRE1/XBP1 and endoplasmic reticulum signaling

IRE1/XBP1 and endoplasmic reticulum signaling - NCBI

This review highlights the mechanisms underlying IRE1 activation and the IRE1 interactome, which reveals unexpected functions for the UPR.

IRE1/XBP1 and endoplasmic reticulum signaling - from basic to ...

Most cellular protein synthesis, including synthesis of membrane-targeted and secreted proteins, which are critical for cellular and organ crosstalk, ...

IRE1 signaling increases PERK expression during chronic ER stress

In this study, we demonstrate cross talk between the IRE1 and PERK branches of the UPR, wherein IRE1 via XBP1s signaling helps to sustain PERK expression ...

The IRE1/Xbp1 axis restores ER and tissue homeostasis perturbed ...

Retention of excess Notch protein in the endoplasmic reticulum (ER) can lead to altered Notch signaling and cell fate, but the mechanism is not well understood.

The IRE1/XBP1 signaling axis promotes skeletal muscle ... - eLife

The UPR is initiated by three ER transmembrane sensors: protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), inositol-requiring ...

IRE1α-XBP1s pathway promotes prostate cancer by activating c ...

Activation of endoplasmic reticulum (ER) stress/the unfolded protein response (UPR) has been linked to cancer, but the molecular mechanisms ...

IRE1β negatively regulates IRE1α signaling in response to ...

... XBP1 splicing mechanism using endoplasmic reticulum ... P. Walter . 2010 . Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic ...

Mammalian endoplasmic reticulum stress sensor IRE1 signals by ...

Accumulation of misfolded proteins in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR), an intracellular signaling pathway that ...

IRE1α-XBP1 pathway promotes melanoma progression by ...

The IRE1α-XBP1 pathway is the most conserved branch of the unfolded protein response pathways, which are activated during endoplasmic ...

Activation of the canonical ER stress IRE1–XBP1 pathway by insulin ...

We reveal that insulin signaling via AKT controls the expression of XBP1 isoforms and that XBP1u and XBP1s function in different nutritional states to regulate ...

XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response ...

Accumulation of unfolded proteins in the endoplasmic reticulum (ER) activates a transcriptional induction pathway, termed the unfolded protein response (UPR), ...

Signaling Pathways from the Endoplasmic Reticulum and Their ...

Activated ATF6 (ATF6(N)) functions as a transcription factor and induces the expression of ER chaperones and XBP1. Activated IRE1 induces the splicing of XBP1 ...

IRE1α–XBP1 signaling in leukocytes controls prostaglandin ...

Inositol-requiring enzyme 1[α] (IRE1[α])–X-box binding protein spliced (XBP1) signaling maintains endoplasmic reticulum (ER) homeostasis ...

Endoplasmic reticulum stress activates human IRE1α through ... - eLife

Inositol-requiring enzyme 1 (IRE1) is an ER membrane-resident kinase/RNase that mediates signal transmission in the most evolutionarily ...

Targeting the IRE1α/XBP1 Endoplasmic Reticulum Stress Response ...

Upon detecting endoplasmic reticulum (ER) stress, the unfolded protein response (UPR) orchestrates adaptive programs to promote cancer cell survival (13–15).

IRE1/XBP1 and endoplasmic reticulum signaling — from basic to ...

In: Current Opinion in Physiology, Vol. 28, 100552, 08.2022. ... Fu, Fangyi ; Doroudgar, Shirin. / IRE1/XBP1 and endoplasmic reticulum signaling — from basic to ...

IRE1 signaling regulates chondrocyte apoptosis and death fate in ...

IRE1-XBP1 signaling way, Controlling endoplasmic reticulum stress or targeting IRE1α-XBP1 signalling may help to restore the metabolic ...

Role of Endoplasmic Reticulum Stress Sensor IRE1α in Cellular ...

IRE1/XBP1 pathway potentiates the activation of nuclear factor κB, a key ... Protein-tyrosine Phosphatase 1B Potentiates IRE1 Signaling during Endoplasmic ...

The role of the IRE1/XBP1 pathway in modulating autophagy. The ...

Misfolded and unfolded proteins may accumulate as a result of er malfunction, which can initiate the unfolded protein response (uPr) and endoplasmic reticulum ...

[PDF] The IRE1/XBP1 signaling axis promotes skeletal muscle ...

This study has identified a novel signaling axis that link ER stress-induced non-myogenic signaling pathway to myoblast fusion and demonstrates that the ...