IRE1α Implications in Endoplasmic Reticulum Stress|Mediated ...

IRE1α Implications in Endoplasmic Reticulum Stress-Mediated ...

IRE1α has a role in the increased expression of BiP, and pro-insulin during stress and these proteins may act as autoantigens/neoantigens. IRE1α activation ...

IRE1α Implications in Endoplasmic Reticulum Stress-Mediated ...

Inositol-requiring transmembrane kinase/endoribonuclease 1α (IRE1α) is the most prominent and evolutionarily conserved endoplasmic reticulum ...

Endoplasmic reticulum stress activates human IRE1α through ... - eLife

In contrast to previous models, our data indicate that IRE1 exists as a constitutive homodimer at baseline and assembles into small oligomers ...

Decoding non-canonical mRNA decay by the endoplasmic ... - Nature

Inositol requiring enzyme 1 (IRE1) mitigates endoplasmic-reticulum (ER) stress by orchestrating the unfolded-protein response (UPR).

Emerging roles for the ER stress sensor IRE1α in metabolic ...

Activation of IRE1α as a metabolic stress sensor. In addition to protein folding overload within the ER lumen, the mammalian ER-localized transmembrane stress ...

IRE1β negatively regulates IRE1α signaling in response to ...

Our cell and biochemical data show that IRE1β dampens the UPR to ER stress. IRE1β restricts ER stress–induced IRE1α endonuclease activity, as ...

IRE1α RIDD activity induced under ER stress drives neuronal death ...

Under ER stress conditions the downstream activation of JNK by IRE1α signaling might amplify ER-stress apoptotic cell death. According to the ...

Endoplasmic Reticulum Stress–Induced IRE1α Activation Mediates ...

In this study, we found that ER stress–induced inositol-requiring enzyme (IRE)1α activation differentially regulates proinflammatory cytokine gene expression.

Role of Endoplasmic Reticulum Stress Sensor IRE1α in Cellular ...

UPR is mediated by three ER membrane localized sensors IRE1α, PERK, and activating transcription factor 6 (ATF6), which induce different interconnected ...

Endoplasmic Reticulum Stress Sensor IRE1α Enhances IL-23 ...

Indeed, stimulation of DCs with PAMPs in the presence of 2-DG robustly activated inositol-requiring protein 1α (IRE1α) signaling and to a lesser extent the PERK ...

A Molecular Mechanism for Turning Off IRE1α Signaling during ...

This promotes the expression of specific genes to alleviate ER stress, thereby attenuating IRE1α. Although sustained activation of IRE1α is ...

Dynamic changes in complexes of IRE1α, PERK, and ATF6α during ...

While PERK complexes shift to large complexes, ATF6α complexes are reduced to smaller complexes on ER stress. In contrast, IRE1α complexes were ...

ER stress and distinct outputs of the IRE1α RNase control ... - PNAS

During ER stress, the inositol requiring enzyme 1α (IRE1α) endoribonuclease (RNase), a key mediator of the UPR, cleaves Xbp1 mRNA to generate a ...

ER Ca2+ overload activates the IRE1α signaling and promotes cell ...

Our data establish a causal link between excess Ca 2+ in ER stores and the selective activation of IRE1α-XBP1 axis, underscoring an unexpected role of overload ...

Endoplasmic reticulum stress activates human IRE1α through ...

Protein folding homeostasis in the endoplasmic reticulum (ER) is regulated by a signaling network, termed the unfolded protein response (UPR).

(PDF) IRE1α Implications in Endoplasmic Reticulum Stress ...

IRE1α has a role in the increased expression of BiP, and pro-insulin during stress and these proteins may act as autoantigens/neoantigens. IRE1α ...

The Emerging Roles of Endoplasmic Reticulum Stress in Balancing ...

In line with this consideration, inhibitors of ER stress signaling components including IRE1α, XBP1, PERK, ATF6, and CHOP has been developed. However, most of ...

IRE1α Implications in Endoplasmic Reticulum Stress-Mediated ...

IRE1α Implications in Endoplasmic Reticulum Stress-Mediated Development and Pathogenesis of Autoimmune Diseases · List of references.

IRE1α Cleaves Select microRNAs During ER Stress to ... - Science

However, if ER stress is irremediable, sustained IRE1α RNase activity triggers cell death. Severe ER stress activates the protease Caspase-2 as ...

Mild Endoplasmic Reticulum Stress Augments the Proinflammatory ...

ER stress enhances the proinflammatory effect of IL-1β but not TNF-α. This effect is mediated by the IRE1α/XBP1s branch of the UPR via modulation of FoxO1 and ...