IRE1α protects against osteoarthritis by regulating progranulin ...

This study investigates the role of IRE1α/ERN1 in OA. Specific deficiency of ERN1 in chondrocytes spontaneously resulted in OA-like cartilage destruction.

Mechanistically, progranulin (PGRN), an intracellular chaperone, binds to IRE1α, promoting its phosphorylation and splicing of XBP1u to generate ...

(PDF) IRE1α protects against osteoarthritis by regulating progranulin ...

IRE1α protects against osteoarthritis by regulating progranulin-dependent XBP1 splicing and collagen homeostasis. November 2023; Experimental and Molecular ...

IRE1α protects against osteoarthritis by regulating progranulin ...

IRE1α protects against osteoarthritis by regulating progranulin-dependent XBP1 splicing and collagen homeostasis. Liang, Li; Zhang, Fengmei; Feng, Naibo; ...

IRE1α protects against osteoarthritis by regulating progranulin ...

IRE1α protects against osteoarthritis by regulating progranulin-dependent XBP1 splicing and collagen homeostasis ... Authors: Li Liang; Fengmei Zhang; Naibo Feng ...

IRE1α protects against osteoarthritis by regulating progranulin ...

Osteoarthritis (OA) is a full-joint, multifactorial, degenerative and inflammatory disease that seriously affects the quality of life of patients due to its ...

IRE1α protects against osteoarthritis by regulating progranulin ...

XBP1s protects articular cartilage through TNF-α/ERK1/2 signaling and further maintains collagen homeostasis by regulating type II collagen expression. The ...

[PDF] The IRE1/XBP1 signaling axis promotes skeletal muscle ...

IRE1α protects against osteoarthritis by regulating progranulin-dependent XBP1 splicing and collagen homeostasis · L. LiangFengmei Zhang +15 authors. Feng-jing ...

Progranulin protects against osteoarthritis through interacting with TNF

Furthermore, PGRN activated extracellular signal-regulated kinases (ERK) 1/2 signalling and elevated the levels of anabolic biomarkers in human chondrocyte, and ...

Articles in 2023 | Experimental & Molecular Medicine - Nature

IRE1α protects against osteoarthritis by regulating progranulin-dependent XBP1 splicing and collagen homeostasis. Li Liang; Fengmei Zhang; Fengjin Guo. Article ...

Citations to this article in year 2023 (4) - JCI

Title and authors, Publication, Year. Protection of inositol-requiring enzyme 1α against osteoarthritis by regulating progranulin-dependent ...

IRE1α dissociates with BiP and inhibits ER stress-mediated ...

Article citations. IRE1α protects against osteoarthritis by regulating progranulin-dependent XBP1 splicing and collagen homeostasis. Liang L, Zhang F, Feng N ...

Progranulin protects against osteoarthritis through interacting with ...

PGRN was found to play a therapeutic role in inflammatory arthritis mice models through antagonising tumour necrosis factor α (TNF-α).

Complex hydrogel for cartilage regeneration and anti-inflammation

Feng, et al. IRE1α protects against osteoarthritis by regulating progranulin-dependent XBP1 splicing and collagen homeostasis. Exp Mol Med ...

Progranulin protects against osteoarthritis through interacting with ...

Furthermore, PGRN activated extracellular signal-regulated kinases (ERK) 1/2 signalling and elevated the levels of anabolic biomarkers in human chondrocyte, and ...

Guilu Erxian glue reduces endoplasmic reticulum stress ... - Cell Press

40. Liang, L. ∙ Zhang, F. ∙ Feng, N. ... IRE1alpha protects against osteoarthritis by regulating progranulin-dependent XBP1 splicing and ...

Progranulin derivative Atsttrin protects against early osteoarthritis in ...

Importantly, PGRN is also a growth factor involved in regulating cartilage development and degradation, and the PGRN level is significantly increased in OA ...

Progranulin regulation of autophagy contributes to its ... - OUCI

Wei, Progranulin derivative Atsttrin protects against early osteoarthritis in mouse and rat models, Arthritis Res Ther, № 19, с. · Xia, Intra-articular ...

Progranulin is required for proper ER stress response and inhibits ...

... protection against apoptosis in response to ER-stress. ... Progranulin regulation of autophagy contributes to its chondroprotective effect in osteoarthritis.

Accepted Archives - Page 525 of 2659 - International Association for ...

IRE1α protects against osteoarthritis by regulating progranulin-dependent XBP1 splicing and collagen homeostasis. Osteoarthritis (OA) is a full-joint ...