Identification and functional characterization of imatinib|sensitive ...

Identification and functional characterization of imatinib-sensitive ...

Eosinophilia-associated myeloid neoplasms with rearrangement of chromosome bands 5q31-33 are frequently associated with PDGFRB fusion genes.

Identification and functional characterization of imatinib‐sensitive ...

2007. Low-dose imatinib mesylate leads to rapid induction of major molecular responses and achievement of complete molecular remission in FIP1L1 ...

Identification and functional characterization of imatinib‐sensitive ...

Identification and functional characterization of imatinib‐sensitive DTD1‐PDGFRB and CCDC88C‐PDGFRB fusion genes in eosinophilia‐associated myeloid/lymphoid ...

Identification of Novel Imatinib-Resistant Genes in Gastrointestinal ...

Third, we verified these genes and identified three prominent differential expression genes by PCR between the imatinib-sensitive cell line ...

Phenotypic and functional characterization of subpopulation of ...

Imatinib (IMA) is a tyrosine kinase inhibitor which is used as a first line therapy option for CML patients [2]. Continuous IMA exposure may lead to the ...

Phenotypic and functional characterization of subpopulation of ...

Imatinib (IMA) is considered as the first line therapy in management of CML which particularly targets the BCR-ABL tyrosine kinase protein. However, emergence ...

Screening and identification of key genes in imatinib-resistant ...

Identification of DEGs in imatinib-resistant CML cells ... We performed differential analysis of 24 samples of imatinib-resistant CML and 24 ...

Identification and functional characterization of the miRNA-gene ...

Earlier reports suggest that primary lin(−) cells are resistant to imatinib even at higher concentrations. So we have used 5 μM imatinib for 48 ...

Structure-based analysis and biological characterization of imatinib ...

The results of our structure-based analysis and biological characterization of imatinib derivatives towards the inhibition of wild-type BCR-ABL and its mutants

Bioinformatic analysis of the expression profile and identification of ...

Chronic myeloid leukemia (CML) is an aggressive malignancy originating from hematopoietic stem cells. Imatinib (IM), the first-generation ...

The development of imatinib as a therapeutic agent for chronic ...

Mutations in the kinase domain (KD) of BCR-ABL that impair imatinib binding have been identified as the leading cause of resistance. Patients with CCR who ...

Genomic and clinical characterization of a familial GIST kindred ...

Clinical reports have shown the relationship between exon-specific KIT variants and response to imatinib, including better sensitivity to ...

Functional consequence of MDR1 expression on imatinib ...

Several other cellular mechanisms of resistance to imatinib have also been identified,2-4 but the possible importance of drug-transporter ...

Identification and Characterization of the Copy Number Dosage ...

18. Yan, Z. ∙ Liu, Y. ∙ Wei, Y. ... The functional consequences and prognostic value of dosage sensitivity in ovarian cancer. Mol. Biosyst ...

Genomic Identification and Functional Characterization of Essential ...

We identified 60 essential genes from 104 lethal mutations in two genomic regions of Caenorhabditis elegans totaling ∼14 Mb on chromosome III(mid) and ...

Identification and functional characterization of i-motifs in plants

iMs are prevalent in human and plant genomes. iMs are relatively more enriched in promoters, exons, and distal intergenic regions in rice, while ...

Molecular Identification and Functional Characterization of a ...

Rationale: Cardioprotective pathways may involve a mitochondrial ATP-sensitive potassium (mitoKATP) channel but its composition is not fully ...

Functional Characterization and Anatomical Identification of Motion ...

All recorded neurons were motion-sensitive. Some of the homolateral neurons respond only with graded potentials to visual stimulation; all ...

Linking functionally related genes by sensitive and ... - PNAS

... characterization of genetic networks and functional modules. We developed a ... TC Fleischer, et al., Systematic identification and functional screens ...

Imatinib: Uses, Interactions, Mechanism of Action | DrugBank Online

Imatinib is indicated for the treatment of adult and pediatric chronic myeloid leukemia with Philadelphia chromosome mutation (Ph+) in blast crisis, accelerated ...