Identification and functional characterization of imatinib‐sensitive

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Characterization of an imatinib-sensitive subset of high ... - PubMed

Supervised analyses of gene expression profiles and real-time PCR analyses identified expression of the chemokine CXCL12/SDF-1 (stromal cell-derived factor 1) ...

Phenotypic and functional characterization of subpopulation of ...

Imatinib (IMA) is considered as the first line therapy in management of CML which particularly targets the BCR-ABL tyrosine kinase protein. However, emergence ...

Screening and identification of key genes in imatinib-resistant ...

We performed differential analysis of 24 samples of imatinib-resistant CML and 24 samples of imatinib-sensitive CML. After standardization of ...

Identification and functional characterization of the miRNA-gene ...

We have earlier shown that a combination of imatinib and JAK inhibitor I can significantly bring down the proliferation of CML lineage negative ...

Identification and Functional Significance of Genes Regulated by ...

Abstract. Imatinib is an ABL-specific inhibitor that binds with high affinity to the inactive conformation of the BCR-ABL tyrosine kinase ...

High-resolution melting analysis is a sensitive diagnostic tool to ...

The detection of mutations in exon 18 of PDGFRA is highly relevant because several mutational subtypes such as p.D842V are associated with primary resistance to ...

The development of imatinib as a therapeutic agent for chronic ...

Enzyme kinetics suggest that imatinib functions as a competitive inhibitor of ATP binding to the ABL kinase with a inhibition constant (Ki) value of 85 nM for c ...

Genomic and clinical characterization of a familial GIST kindred ...

Clinical reports have shown the relationship between exon-specific KIT variants and response to imatinib, including better sensitivity to ...

end KIT juxtamembrane deletion in a duodenal GIST treated with ...

This analysis clearly demonstrate that Imatinib binds to the inactivated forms of the newly reported deletion mutant Δ574–580 with affinity ...

Identification of exosomal microRNAs and related hub genes ...

... functional characterization of subpopulation of Imatinib resistant chronic myeloid leukemia cell line. ... sensitive cells in the presence ...

Characterization of imatinib-resistant K562 cell line displaying ...

Results indicate that inhibition of apoptosis, induction of autophagy, overexpression of efflux gene MDR1 and down-regulation of influx gene OCT1 play ...

Quantitative Proteomic Analysis of Plasma Exosomes to Identify the ...

Compared with imatinib-sensitive CML patients, 151 proteins were up-regulated and 128 proteins were down-regulated. Bioinformatics analyses revealed that the ...

Imatinib in myeloid/lymphoid neoplasms with eosinophilia and ...

Gosenca D, Kellert B, Metzgeroth G et al (2014) Identification and functional characterization of imatinib-sensitive DTD1-PDGFRB and CCDC88C-PDGFRB fusion ...

Gene expression profiling of imatinib and PD166326-resistant CML ...

Hence, we investigated the effect of imatinib and PD166326 on the regulation of cell cycle in parental, IM-R, and PD-R K562 cells. A decrease of ...

Proteomic analysis of imatinib-resistant CML-T1 cells reveals ...

Imatinib is the first tyrosine kinase inhibitor (TKI) drug approved for CML therapy which blocks the ATP-binding site of Bcr-Abl and inhibits ...

kfw032.pdf - Oxford Academic

fied as a resistance factor in the imatinib functional screening ... Functional characterization of the S. cerevisiae genome by gene ...