Identification and functional characterization of imatinib‐sensitive ...

Characterization of an imatinib-sensitive subset of high ... - PubMed

Supervised analyses of gene expression profiles and real-time PCR analyses identified expression of the chemokine CXCL12/SDF-1 (stromal cell-derived factor 1) ...

Phenotypic and functional characterization of subpopulation of ...

Imatinib (IMA) is a tyrosine kinase inhibitor which is used as a first line therapy option for CML patients [2]. Continuous IMA exposure may lead to the ...

Screening and identification of key genes in imatinib-resistant ...

We performed differential analysis of 24 samples of imatinib-resistant CML and 24 samples of imatinib-sensitive CML. After standardization of ...

Identification of Novel Imatinib-Resistant Genes in Gastrointestinal ...

A total of 897 differentially expressed genes (DEGs) were found between imatinib-sensitive cell line GIST882 and imatinib-resistant cell line ...

Identification and functional characterization of the miRNA-gene ...

Earlier reports suggest that primary lin(−) cells are resistant to imatinib even at higher concentrations. So we have used 5 μM imatinib for 48 ...

Phenotypic and functional characterization of subpopulation of ...

Imatinib (IMA) is considered as the first line therapy in management of CML which particularly targets the BCR-ABL tyrosine kinase protein. However, emergence ...

The development of imatinib as a therapeutic agent for chronic ...

Mutations in the kinase domain (KD) of BCR-ABL that impair imatinib binding have been identified as the leading cause of resistance. Patients with CCR who ...

Characterization of imatinib-resistant K562 cell line displaying ...

Results indicate that inhibition of apoptosis, induction of autophagy, overexpression of efflux gene MDR1 and down-regulation of influx gene OCT1 play ...

Identification and Functional Significance of Genes Regulated by ...

Abstract. Imatinib is an ABL-specific inhibitor that binds with high affinity to the inactive conformation of the BCR-ABL tyrosine kinase ...

end KIT juxtamembrane deletion in a duodenal GIST treated with ...

This analysis clearly demonstrate that Imatinib binds to the inactivated forms of the newly reported deletion mutant Δ574–580 with affinity ...

Identification of exosomal microRNAs and related hub genes ...

... functional characterization of subpopulation of Imatinib resistant chronic myeloid leukemia cell line. ... sensitive cells in the presence ...

Proteomic analysis of imatinib-resistant CML-T1 cells reveals ...

Imatinib is the first tyrosine kinase inhibitor (TKI) drug approved for CML therapy which blocks the ATP-binding site of Bcr-Abl and inhibits ...

Gene expression profiling of imatinib and PD166326-resistant CML ...

Hence, we investigated the effect of imatinib and PD166326 on the regulation of cell cycle in parental, IM-R, and PD-R K562 cells. A decrease of ...

Imatinib in myeloid/lymphoid neoplasms with eosinophilia and ...

Gosenca D, Kellert B, Metzgeroth G et al (2014) Identification and functional characterization of imatinib-sensitive DTD1-PDGFRB and CCDC88C-PDGFRB fusion ...

Quantitative Proteomic Analysis of Plasma Exosomes to Identify the ...

Compared with imatinib-sensitive CML patients, 151 proteins were up-regulated and 128 proteins were down-regulated. Bioinformatics analyses revealed that the ...

Integrated drug profiling and CRISPR screening identify BCR::ABL1 ...

To assess the drug sensitivity profile of CML-LSPCs, we performed ex vivo DSRT for samples from 20 CML patients (Table S1), including 4 accelerated phase/blast ...