Identification of Oct4|activating compounds that enhance ...

Identification of Oct4-activating compounds that enhance ... - PNAS

To identify small molecules that enhance reprogramming efficiency, we performed a cell-based high-throughput screening of chemical libraries. One of the ...

Identification of Oct4-activating compounds that enhance ... - PubMed

To identify small molecules that enhance reprogramming efficiency, we performed a cell-based high-throughput screening of chemical libraries.

(PDF) Identification of Oct4-activating compounds that enhance ...

To identify small molecules that enhance reprogramming efficiency, we performed a cell-based high-throughput screening of chemical libraries.

Identification of Oct4-activating compounds that enhance ...

One of the hurdles for practical application of induced pluripotent stem cells (iPSC) is the low efficiency and slow process of reprogramming.

Fig. 1. Identification of Oct4-activating compounds. (A) Expression of...

Oct4-activating compounds (OAC1 and OAC2) enhanced the efficiency of OSKM-induced iPSC generation [34] . Furthermore, one or more OSKM-reprogramming factors can ...

Identification of Small Activating RNAs that Enhance Endogenous ...

2A), suggesting that these compounds have no apparent effect on OCT4 expression nor on dsOCT4-622 activity. However, in the presence of 1 mM VPA, dsOCT4-622 ...

Identification of Oct4-activating compounds that enhance ...

Identification of Oct4-activating compounds that enhance reprogramming efficiency. Wendong Li, E. Tian, Zhao Xia Chen, Guo Qiang Sun, Peng Ye, Su Yang, Dave ...

Identification of Oct4-activating compounds that enhance ... - Altmetric

Identification of Oct4-activating compounds that enhance reprogramming efficiency · Proceedings of the National Academy of Sciences of the United States of ...

Identification of Oct4-activating compounds that enhance ...

Identification of Oct4-activating compounds that enhance reprogramming efficiency. ... In this study, we identified a novel small molecule compound, termed Oct4 ...

Li, et al. (2012) Identification of Oct4-activating compounds that ...

Li, et al. (2012) Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proceedings of the National Academy of Sciences, 109, ...

Oct-4 activating compound 1 (OAC1) could improve the quality of ...

The POU5F1 protein (POU domain, class 5, transcription factor 1) was first identified as a major transcription factor in embryonic stem cells ( ...

OCT4 Activator | TCI AMERICA

References · 1)Identification of Oct4-activating compounds that enhance reprogramming efficiency. W. Li, E. · 2)Small-molecule-based lineage reprogramming creates ...

Identification of Small Activating RNAs that Enhance Endogenous ...

By screening of dsRNAs targeting OCT4 promoter, we identified a small activating RNA (saRNA) that activated OCT4 expression in several types of human ...

OAC1 - STEMCELL Technologies

OAC1 is an OCT-4-activating compound that activates expression through the OCT-4 gene promoter (Li et al.).

Role of Oct4 in maintaining and regaining stem cell pluripotency

In the past several years, genome-wide identification of Oct4 target genes and Oct4-centered protein interactomes has been reported, indicating ...

Biological importance of OCT transcription factors in reprogramming ...

Attempts to identify genes or chemicals that can functionally replace each of these four reprogramming factors have revealed that exogenous Oct4 ...

Development of a next-generation endogenous OCT4 inducer and ...

Recently, we conducted high-throughput screening and identified a series of compounds called OCT4-inducing compounds (O4Is). These compounds ...

In silico identification of natural product inhibitors against Octamer ...

Oct4 maintained the cancer cell survival partly by inhibiting apoptosis through the Oct4/TCL1/AKT1 pathway where Tcl1 enhances the kinases ...

Modaline sulfate promotes Oct4 expression and maintains self ...

In summary, we have firstly identified a small molecule, modaline sulfate (MDLS), enhanced Oct4 and maintained the self-renewal and pluripotency ...

Oct4 is a gatekeeper of epithelial identity by regulating cytoskeletal ...

through the Toca-1 protein, which enhances OCT4 reactivation ... Reprogramming of human primary somatic cells by. OCT4 and chemical compounds.