Identification of Therapy|Induced Clonal Evolution and Resistance ...

Identification of Therapy-Induced Clonal Evolution and Resistance ...

These data suggest that MM cells could rapidly adapt to induction treatment through transcriptional adaptation, metabolic adaptation, ...

Identification of Therapy-Induced Clonal Evolution and Resistance ...

Here, we use single-cell RNA sequencing (scRNA-seq) to identify the clonal architecture at diagnosis and after induction therapy, and elucidate ...

Identification of Therapy-Induced Clonal Evolution and Resistance ...

AbstractPurpose:. In multiple myeloma (MM), therapy-induced clonal evolution is associated with treatment resistance and is one of the most important.

Identification of Therapy-Induced Clonal Evolution and Resistance ...

Previous studies have confirmed that clonal evolution frequently occurs at disease follow-up, and the patterns of clonal evolution between ...

Identification of Therapy-Induced Clonal Evolution and Resistance ...

Our study confirms that clonal dynamics of the evolving PC clones may occur early after upfront therapy, and reveals that the acquisition of therapeutic ...

Identification of Therapy-Induced Clonal Evolution and Resistance ...

Purpose: In multiple myeloma (MM), therapy-induced clonal evolution is associated with treatment resistance and is one of the most important ...

Clonal Evolution and Therapeutic Resistance in Solid Tumors - NCBI

The presence of admixtures of non-neoplastic cells in patient samples can obscure the detection of somatic aberrations including mutations, homozygous deletions ...

Functional lineage tracing to study the clonal evolution of therapy ...

Despite many significant advances in cancer therapies, resistance still remains a critical problem preventing durable responses and complete ...

Identification of Therapy-Induced Clonal Evolution and Resistance ...

Abstract Purpose: In multiple myeloma (MM), therapy-induced clonal evolution is associated with treatment resistance and is one of the most important ...

How Darwinian models inform therapeutic failure initiated by clonal ...

This review summarises the evidence for the evolution of resistance to cytotoxic and targeted anti-cancer drugs according to Darwinian models

Identification of Therapy-Induced Clonal Evolution and Resistance ...

Identification of Therapy-Induced Clonal Evolution and Resistance Pathways in Minimal Residual Clones in Multiple Myeloma through Single-Cell Sequencing. Cui, ...

Clonal evolution in chronic lymphocytic leukemia is scant in ...

Furthermore, clonal evolution allows the selection of cell populations that are resistant to therapy or responsible for disease recurrence. For ...

The heterogeneity and clonal evolution analysis of the advanced ...

Drug resistant subclones were defined as subclones existing in both pre-and post-treatment tumor samples. Driver genes were annotated for each ...

Identification of Therapy-Induced Clonal Evolution and Resistance ...

Request PDF | Identification of Therapy-Induced Clonal Evolution and Resistance Pathways in MRD Clones in Multiple Myeloma through Single-Cell Sequencing ...

Tumor Evolution as a Therapeutic Target | Cancer Discovery

As clonal evolution is defined by changes of tumor heterogeneity over both space and time (temporal heterogeneity), its analysis requires the ability to track ...

Tumour heterogeneity and the evolution of polyclonal drug resistance

At a cellular level, intrinsic resistance arises due to the presence of a resistance mechanism in the tumour cells prior to treatment, whereas ...

Clonal Heterogeneity and Tumor Evolution: Past, Present, and the ...

Despite these advances, knowledge of ITH and clonal evolution and the potential for competitive release of resistant subclones is infrequently ...

Clonal evolution and therapeutic resistance in solid tumors

Our work has identified examples of clonal resistance to effective therapies. This includes androgen withdrawal in advanced prostate cancer. In addition we ...

[PDF] Identification of Therapy-Induced Clonal Evolution and ...

Abstract Purpose: In multiple myeloma (MM), therapy-induced clonal evolution is associated with treatment resistance and is one of the most important ...

Clonal evolution in chronic lymphocytic leukemia: acquisition of high ...

Expansion of the clone with del(17p13) was observed in all patients during treatment, indicating resistance to therapy. In multivariable ...