Identification of Tissue of Origin and Guided Therapeutic ...

Identification of Tissue of Origin and Guided Therapeutic ... - PubMed

Cancers of unknown primary (CUP) are metastatic cancers for which the primary tumor is not found despite thorough diagnostic investigations.

We developed a classifier tool based on the training of a variational autoencoder to predict tissue of origin based on RNA-sequencing data.

Identification of Tissue of Origin and Guided Therapeutic ...

Identification of Tissue of Origin and Guided Therapeutic Applications in Cancers of Unknown Primary Using Deep Learning and RNA Sequencing ...

Identification of tissue of origin in carcinoma of unknown primary ...

... guide targeted therapy in patients with colorectal cancer profiles. Such changes in CUP therapy directed by molecular profiling might reasonably be expected ...

Identification of Tissue of Origin and Guided Therapeutic ...

Les publications (old) · Identification of Tissue of Origin and Guided Therapeutic Applications in Cancers of Unknown Primary Using Deep Learning and RNA ...

New techniques to identify the tissue of origin for cancer of unknown ...

, et al. Identification of tissue of origin and guided therapeutic applications in cancers of unknown primary using deep learning and RNA ...

TumorTracer: a method to identify the tissue of origin from the ...

It has been previously demonstrated that the somatic point mutations detected in a tumor can be used to identify its site of origin with limited accuracy.

RNA-seq and AI for CUP - ScienceDirect.com

Identification of tissue of origin and guided therapeutic applications in cancers of unknown primary using deep learning and RNA sequencing (TransCUPtomics).

Site-specific therapy guided by a 90-gene expression assay versus ...

Gene-expression profiling assays have been developed to identify the tissue of origin in patients with CUP; however, their clinical benefit has ...

Case Report: Tissue Origin Identification for Cancer of Unknown ...

Then all patients received accurate treatment, providing reference to guide therapeutic decisions to treat CUP tumors in the future. Introduction. Cancer of ...

Personalized Therapy Selection by Integration of Molecular Cancer ...

... guided biomarker analysis to identify the tissue of origin and actionable biomarkers. Context. Key Objective. To assess whether molecular ...

October 2021 - The Journal of Molecular Diagnostics

... Identification of Tissue of Origin and Guided Therapeutic ...

The Role of Tissue-of-Origin Molecular Profiling - AACR Journals

Beyond ToO determination, newer genomic methods drawn from non-CUP cancer experience attempt to use individual tumor data to help guide a personalized cancer ...

Targeted therapy guided by circulating tumor DNA analysis in ...

... tissue of origin, and other potential imbalances between the groups. ... detection of biomarkers compared with tissue testing. This gap ...

Utility of RNA Expression to Determine the Tissue of Origin of ...

Identification of tissue of origin and guided therapeutic applications in cancers of unknown primary using deep learning and RNA sequencing ...

Identification of tissue of origin in carcinoma of unknown primary ...

... guide targeted therapy in patients with colorectal cancer profiles. Such changes in CUP therapy directed by molecular profiling might ...

Gene Expression Assay Shows Ability to Guide Targeted Treatment ...

... treatment guided by Canhelp-Origin was superior to empiric ... Origin's tissue-or-origin determination yield an overall survival benefit.

Molecularly guided therapy versus chemotherapy after disease ...

Studies have shown that gene expression-profiling-based tissue-of-origin identification with subsequent primary site-directed therapy did not ...

A cfDNA methylation-based tissue-of-origin classifier for cancers of ...

Patients with cancer were recruited through the TARGET (Tumour Characterisation to Guide Experimental Targeted Therapy) trial. Ethical approval ...

Role of molecular diagnostics in determination of tissue of origin in ...

Hence, it is important to diagnose the cancer type in patients with difficult to diagnose cancers to further guide the choice of site-specific therapy.