Immune Profiling|Based Targeting of Pathogenic T Cells with ...

Immune profiling-based targeting of pathogenic T cells with ... - Nature

We treat four ANCA-GN patients with ustekinumab, which specifically targets Th1 and Th17 cells, as add-on therapy.

Immune profiling-based targeting of pathogenic T cells with ...

Immune profiling-based targeting of pathogenic T cells with ustekinumab in ANCA-associated glomerulonephritis. Nat Commun. 2024 Sep 19;15(1):8220. doi: ...

Immune pro ling-based targeting of pathogenic T cells with ...

Our ndings suggest that immune-pro ling-based targeting of pathogenic T cells in ANCA-GN patients with ustekinumab is a promising approach ...

(PDF) Immune profiling-based targeting of pathogenic T cells with ...

Our findings thus suggest that targeting of pathogenic T cells in ANCA-GN patients with ustekinumab might represent a potential approach and ...

Katalin Susztak on X: "Immune profiling-based targeting of ...

Immune profiling-based targeting of pathogenic T cells with ustekinumab in ANCA-associated glomerulonephritis | @NatureComms ...

Immune Profiling-Based Targeting of Pathogenic T Cells with ...

Immune Profiling-Based Targeting of Pathogenic T Cells with Ustekinumab in ANCA-Associated Glomerulonephritis: SA-PO756 · October 2024 · Journal ...

T cells | Nature Communications

The efficiency of antibody-based immune checkpoint blockades could be compromised by the intracellular accumulation of checkpoint proteins. Here authors show ...

Targeting cytotoxic T lymphocytes for cancer immunotherapy - PMC

Cytotoxic T lymphocytes represent a crucial component of the adaptive immune system with particular importance in the control of intracellular pathogens.

Immune-based, multifaceted inactivation of pathogenic T ...

Immunotherapeutic treatment of autoimmune diseases should aim to inactivate autoaggressive memory T-cells and restore immune tolerance.

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in ...

Understanding adaptive immunity to SARS-CoV-2 is important for vaccine development, interpreting coronavirus disease 2019 (COVID-19) pathogenesis, ...

Single-cell transcriptomic profiling reveals a pathogenic role of ...

Our results revealed an expansion of cytotoxic CD4 + T lymphocytes (CTLs) in active GCA patients, which expressed higher levels of cytotoxic and chemotactic ...

Single-cell immune profiling reveals functional diversity of T cells in ...

Granzyme K–expressing CD8 T cells were preferentially enriched and clonally expanded in pleural fluid from TPE, suggesting that they are ...

Dual receptor T cells mediate effective antitumor immune responses ...

Phenotype and single-cell gene expression analyses identified dual TCR are predominant during the effective antitumor response, demonstrating selectively ...

CAR T Cells: Engineering Immune Cells to Treat Cancer - NCI

The CAR T-cell therapies approved by FDA to date target one of two antigens on B cells, CD19 or BCMA. Making a CAR T Cell. A growing number of ...

Gamma delta T-cell-based immune checkpoint therapy

Studies have shown that targeting ICs can reverse the dysfunctional state of γδT cells in the tumor microenvironment (TME) and exert antitumor ...

Review article Role of T cells in cancer immunotherapy

This review addresses all the strategies targeting tumor pathogenesis, including metabolic pathways, to evaluate the clinical significance of current and ...

Tumor-infiltrating γδ T lymphocytes: pathogenic role, clinical ...

T cells carrying the γδ T cell receptor (TCR) are important effector cells that may play a role in the anti-tumor immune response. γδ Cells are not a ...

Single-cell transcriptomics identifies pathogenic T-helper 17.1 cells ...

The CD4+ T-cell compartment showed an increase of pathogenic T-helper 17.1 cells, characterized by high co-expression of TBX21 (encoding T-bet) and RORC (ROR-γ) ...

CD4 T-cell Subsets and Tumor Immunity: The Helpful and the Not-so ...

Nevertheless, the antitumor activity of these CD4 cells soon became apparent based on their ability to prevent virus-induced sarcomas, to eradicate disseminated ...

KIR+CD8+ T cells suppress pathogenic T cells and are active in ...

The frequency of KIR+CD8+ T cells was higher in the blood and inflamed tissues of patients with multiple autoimmune diseases compared with those ...