Immune ageing at single|cell resolution

Immune ageing at single-cell resolution | Nature Reviews Immunology

Here we review a body of recent studies that explored how the immune system ages using unbiased profiling techniques at single-cell resolution.

IMMUNE AGING AT SINGLE-CELL RESOLUTION - Oxford Academic

I will discuss how single-cell resolution approaches reveal aspects of immune aging in tissues and in circulation. We will discuss comparison of ...

Unveiling the immune system aging in single-cell resolution

This commentary first summarizes the spatial-temporal dynamics of regulatory T cells derived from mice (Tabula Muris Senis) of different ages (3, 18, and 24 mo)

Immune ageing at single-cell resolution - De Anza College

Ageing leads to profound alterations in the immune system and increases susceptibility to some chronic, infectious and autoimmune diseases.

Single-cell profiling of immune system alterations in lymphoid ...

To create a comprehensive immune-phenotyping map as a resource to compare cellular changes between young and aged mice, we aimed to measure age- ...

Single-cell immune atlas for human aging and frailty - PMC - NCBI

As expected, an age-dependent accumulation of cellular heterogeneity and transcriptomic variability across the immune cell subtypes was evident. Compared to the ...

Single-cell atlas of healthy human blood unveils age

Subclustering resolution of major immune subtypes was chosen such that it generally matched transcriptional signa- tures of biologically well- ...

Immune ageing at single-cell resolution - ResearchGate

Request PDF | Immune ageing at single-cell resolution | Ageing leads to profound alterations in the immune system and increases susceptibility to some ...

Comprehensive Profiling of an Aging Immune System Reveals ...

In humans, proportions of the circulating GZMK+CD8+ T cell population that shares transcriptional and epigenetic signatures with mouse Taa cells ...

Effects of sex and aging on the immune cell landscape as assessed ...

Moreover, cell–cell communication analysis revealed evidence of increased activity of the BAFF/APRIL systems in females. Notably, aging ...

Single-cell atlas of healthy human blood unveils age-related loss of ...

The human immune system changes substantially during aging, even in the absence of disease. Understanding age-associated changes in human PBMCs has served as ...

The impact of aging and COVID-19 on our immune system

In addition, T cell and B cell receptor diversity was also found to decrease with age. Consistent with these findings, a recent systematic ...

A human circulating immune cell landscape in aging and COVID-19

Age-associated changes in immune cells have been linked to an increased risk for infection. However, a global and detailed characterization ...

Unveiling the immune system aging in single-cell resolution

Age-related immunosenescense is characterized by progressive dysfunction of adaptive immune response and increased autoimmunity. Nevertheless, ...

Single-cell analysis of the aged ovarian immune system reveals a ...

We show that the composition of the immune cells undergoes an extensive shift with age towards adaptive immunity.

Deciphering the impact of aging on splenic endothelial cell ...

In this study, a single-cell RNA (scRNA) atlas of EC transcriptomes from young and aged mouse spleens was constructed to reveal age-related ...

Unveiling the immune system aging in single-cell resolution - OUCI

in 2023, published in the Journal of Leukocyte Biology. This commentary first summarizes the spatial-temporal dynamics of regulatory T cells derived from mice ( ...

Ageing leads to breakdown in cell coordination

Their findings, published today in Science, show that immune cells in older tissues lack coordination and exhibit much more variability in gene ...

Multi-modal profiling of peripheral blood cells across the human ...

Age-related changes in immune cell composition and functionality are associated with multimorbidity and mortality.

Establishing a human bone marrow single cell reference atlas to ...

To date, most immune ageing studies employed flow cytometry to analyse peripheral blood samples (1). Flow cytometry has high throughput and is ...