Immunodominant T|cell epitopes from the SARS|CoV|2 spike ...

Immunodominant T-cell epitopes from the SARS-CoV-2 spike ...

Most immunogenic epitopes activated CD8 T-cells at 48 h and achieved > 2% activation by 7-day. The early activation at 48 h suggested that these ...

Prevalent and immunodominant CD8 T cell epitopes are conserved ...

221 cell lines overexpressing the SARS-CoV-2 structural proteins spike (S, 3 truncated proteins), membrane (M), envelope (E), or nucleocapsid (N) ...

SARS-CoV-2 epitope-specific T cells: Immunity response feature ...

The magnitude of CD4+ and CD8+ T cell response is closely related to almost all SARS-CoV-2 proteins, but a few virus antigens [spike, nucleocapsid, Membrane, ...

Immunodominant T-cell epitopes from the SARS-CoV-2 spike ...

Most immunogenic epitopes activated CD8 T-cells at 48h and achieved >2% activation by 7-day, suggesting that these epitopes engaged pre-existing ...

Nonconserved epitopes dominate reverse preexisting T cell ... - Nature

Immunodominant T-cell epitopes from the SARS-CoV-2 spike antigen reveal robust pre-existing T-cell immunity in unexposed individuals. Article ...

T Cell Immunity Evaluation and Immunodominant Epitope ... - Frontiers

These TCR-T cells can be activated by SARS-CoV-2 spike peptide and produce IFN-γ in vitro. These results might provide valuable information for ...

Immunodominant T-cell epitopes from the SARS-CoV-2 spike ...

A selected pool of 11 predicted epitopes induced robust T-cell activation in unexposed donors demonstrating pre-existing CD4 and CD8 T-cell ...

Review SARS-CoV-2 human T cell epitopes - ScienceDirect.com

... cell entry. In the case of the spike protein, several immunodominant regions were observed for CD4 (residues 154–254, 296–370 and 682–925; Figure 2A) ...

Immunogenic T cell epitopes of SARS-CoV-2 are recognized by ...

Emergency vaccines based on the spike protein of the virus have been developed and are currently being administered. Cytotoxic CD8 T cells are ...

SARS-CoV-2 genome-wide T cell epitope mapping reveals ...

Across 10 analyzed HLA molecules, 122 unique SARS-CoV-2 CD8+ T cell epitopes were detected, including 5 immunodominant epitopes primarily concentrated within ...

Structural basis of biased T cell receptor recognition of an ...

... immunodominant HLA-A2 epitope of the SARS-CoV-2 spike protein ... The T cell response directed toward SARS-CoV-2 spike ... 2 CD8+ T cell epitopes ...

The immunodominant and neutralization linear epitopes for SARS ...

predict and validate B cell epitopes on the spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins of SARS-CoV-2 using structure-.

Immune Epitopes of SARS-CoV-2 Spike Protein and Considerations ...

Among the activated CD4+ T cells, T follicular helper cells contribute to B cell activation, plasma cell maturation, and Ab production, whereas Th1 cells help ...

Comprehensive analysis of T cell immunodominance and ...

Unbiased screens show CD8+ T cells of COVID-19 patients recognize shared epitopes in SARS-CoV-2 that largely reside outside the spike protein. Immunity. 2020 ...

Seeing the T cell Immunity of SARS-CoV-2 and SARS-CoV

Structural basis of biased T cell receptor recognition of an immunodominant HLA-A2 epitope of the SARS-CoV-2 spike protein. J Biol Chem ...

Published list of COVID-19 T-cell epitopes - Immudex

Do some people have pre- existing immunity to SARS-. CoV-2? ▫. Are some T-cell epitopes immunodominant? ▫. Are disease ...

Immunodominant T-cell epitopes from the SARS-CoV-2 spike ...

AbstractThe COVID-19 pandemic has revealed a range of disease phenotypes in infected patients with asymptomatic, mild, or severe clinical outcomes, ...

Identification of SARS-CoV-2 Nucleocapsid and Spike T-Cell ...

In the present study, we applied an immunoinformatics analysis pipeline to define immunodominant epitopes in currently circulating SARS-CoV-2 viral variants.

Escape from recognition of SARS-CoV-2 variant spike epitopes but ...

SARS-CoV-2 variants that escape neutralization and potentially affect vaccine efficacy have emerged. T cell responses play a role in protection from ...

SARS-CoV-2 epitopes inform future vaccination strategies - Frontiers

Next-generation vaccines must include sequences from proteins other than spike since many immunodominant T-cell epitopes reside outside the spike protein.