Immunogenic T cell epitopes of SARS|CoV|2 are recognized by ...

Immunogenic T cell epitopes of SARS-CoV-2 are recognized by ...

Our results, based on specific tetramer binding, provide evidence supporting the presence of frequent cross-reactive CD8 T cells to SARS-CoV-2 ...

Immunogenic T cell epitopes of SARS-CoV-2 are recognized by ...

Our results, based on specific tetramer binding, provide evidence supporting the presence of frequent cross-reactive CD8 T cells to SARS-CoV-2 antigens in non- ...

SARS-CoV-2 Epitopes Are Recognized by a Public and Diverse ...

assessed the immune response to SARS-CoV-2 in convalescent patients and healthy donors. Antigen-specific T cells were increased in convalescents ...

Review SARS-CoV-2 human T cell epitopes - ScienceDirect.com

This remarkable breadth of epitope repertoire has implications for vaccine design, cross-reactivity, and immune escape by SARS-CoV-2 variants. Previous article ...

Immunodominant T-cell epitopes from the SARS-CoV-2 spike ...

Therefore, an early wave of strong CD8 T-cell response may delay viral titer build-up, allowing rapid clearance of the virus by the immune ...

SARS-CoV-2 Epitopes Are Recognized by a Public and Diverse ...

Understanding the hallmarks of the immune response to SARS-CoV-2 is critical for fighting the COVID-19 pandemic. We assessed antibody and T cell reactivity in ...

Immune Epitopes of SARS-CoV-2 Spike Protein and Considerations ...

As T cells primarily act to limit viral replication by mediating APC activation, humoral immune response, and destruction of infected cells (Fig. 2), they ...

SARS-CoV-2 epitope-specific T cells: Immunity response ... - Frontiers

The epitope is a critical region for host immune cells to recognize a specific pathogen, also known as antigenic determinant (56). The epitopes ...

SARS-CoV-2-derived peptides define heterologous and COVID-19 ...

Table 3 Immunogenic SARS-CoV-2-derived HLA-DR T cell epitopes ... Alignments of the SARS-CoV-2 T cell epitopes recognized by unexposed ...

Immunogenic epitope panel for accurate detection of non-cross ...

... T cells specific to the panel of immunogenic SARS CoV-2 epitopes. ... epitopes are recognized by a public and diverse repertoire of human T cell ...

SARS-CoV-2 genome-wide T cell epitope mapping reveals ...

... SARS-CoV-2 genome sequence (26) to identify immunogenic minimal epitopes recognized by CD8+ T cells. Using NetMHCpan 4.1 (27), we selected 2204 potential ...

Evolution of SARS-CoV-2-specific CD4 + T cell epitopes

The adaptive immune response against SARS-CoV-2 is dominated by an antiviral T cell response and the production of neutralizing antibodies ( ...

Mass spectrometric identification of immunogenic SARS-CoV-2 ...

In essence, an immunogenic epitope of SARS-CoV-2 requires direct sequencing of peptides presented by MHC as well as empiric validation of T cell immunogenicity.

Selective and cross-reactive SARS-CoV-2 T cell epitopes ... - Science

Many unknowns exist about human immune responses to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus.

Identification of SARS-CoV-2 Nucleocapsid and Spike T-Cell ...

Highlighted in red are the most promising T-cell epitope derived peptides for HLA class I-mediated immune recognition (i.e., those with top 5% scores for HLA ...

Immunogenicity predictions reveal SARS-CoV-2 CD8+ T-cell epitopes

... 2 (SARS-CoV-2) epitopes displayed on human leukocyte antigens class I (HLA-I) molecules. The recognition of these epitopes by the cluster of ...

T cell response to intact SARS-CoV-2 includes coronavirus cross ...

Overall, CD4 T cell epitopes were detected in 13 SARS-CoV-2 proteins. ... The immune epitope database (IEDB) 3.0. Nucleic Acids Res. 2015;43(d1):D405–D412 ...

Immunogenic T cell epitopes of SARS-CoV-2 are recognized by ...

Immunogenic T cell epitopes of SARS-CoV-2 are recognized by circulating memory and naïve CD8 T cells of unexposed individuals. Isaac Quiros ...

Identification of mouse CD4 + T cell epitopes in SARS-CoV-2 BA.1 ...

This additional step addressed the immunogenicity of each epitope when the efficiency by which it is processed from protein and presented by antigen-presenting ...

T Cell Responses to SARS-CoV-2 - Annual Reviews

SARS-CoV-2 human T cell epitopes: adaptive immune response against COVID-19. ... SARS-CoV-2 epitopes are recognized by a public and diverse repertoire of human T ...