Impact of Deficient DNA Mismatch Repair on Disease|Free Survival ...

Impact of Deficient DNA Mismatch Repair on Disease-Free Survival ...

They found that patients with proximal mismatch repair–deficient tumors had favorable outcome, whereas those with distal or N2 mismatch repair– ...

Prognostic impact of deficient DNA mismatch repair in patients with ...

The prognostic impact of MMR depended on tumor site, and this interaction was validated in an independent cohort.

Prognostic Impact of Deficient DNA Mismatch Repair in Patients ...

Impact of mismatch repair (MMR) status on disease-free survival by primary tumor site. Tumor site was categorized as (A) proximal versus (B) distal (see ...

Mismatch repair deficiency/microsatellite instability-high as a ...

Defects in DNA mismatch repair proteins and subsequent microsatellite instability-high lead to the accumulation of mutation loads in cancer- ...

Prognostic Impact of Deficient DNA Mismatch Repair in Patients ...

018) but not dMMR distal tumors (HR, 1.71; 95% CI, 0.99 to 2.95; P = .056), adjusting for mutations and covariates. Any survival benefit of dMMR was lost in N2 ...

Mismatch repair deficiency is not sufficient to elicit tumor ... - Nature

DNA mismatch repair deficiency (MMRd) is associated with a high tumor mutational burden (TMB) and sensitivity to immune checkpoint blockade (ICB) therapy.

Implications of mismatch repair-deficient status on management of ...

Alternatively, the microsatellite instability (MSI) phenotype represents ~15% of all CRCs and is caused by deficient DNA mismatch repair (MMR) as a consequence ...

Effects of deficient mismatch repair on the prognosis of patients with ...

MMR status as a prognostic marker for patients with stage III disease. Among the patients with stage III colon cancer, 12.8% (n = 75) had dMMR.

Clinical and Genetic Implications of DNA Mismatch Repair ...

DNA mismatch repair status is a well-established biomarker in colorectal cancer and is associated with both a favorable prognosis and ...

The Clinical Impact of the Genomic Landscape of Mismatch Repair ...

Tumors carrying defects in DNA MMR accumulate high levels of mutations, a feature linked to rapid tumor progression and acquisition of drug resistance but also ...

Deficient mismatch repair: Read all about it (Review)

Defects in the DNA mismatch repair (MMR) proteins, result in a phenotype called microsatellite instability (MSI), occurring in up to 15% of sporadic colorectal ...

Mismatch Repair Deficiency, Microsatellite Instability, and Survival ...

In contrast, patients treated with chemotherapy plus surgery who had either high MSI or MMRD had a median OS of 9.6 months (95% CI, 0.1-22.5 ...

Clinicopathological significance of deficient DNA mismatch repair ...

Loss of MMR function results from a biallelic inactivation of the key MMR genes: MLH1, PMS2, MSH2, or MSH6. Sporadic disease is more common, and as regards EC, ...

DNA Mismatch Repair Deficiency in Rectal Cancer

MMR deficiency (dMMR) has been associated with a favorable prognosis and a predicted poorer response to fluoropyrimidine-based adjuvant therapy ...

Prognostic and Predictive Values of Mismatch Repair Deficiency in ...

Knowledge of mismatch repair (MMR) status has important implications for disease diagnosis, surgical intervention, and adjuvant treatment ...

Deficient mismatch repair/microsatellite unstable colorectal cancer

Microsatellite unstable (MSI) colorectal cancers (CRCs) are due to DNA mismatch repair (MMR) deficiency and occurs in15% of non-metastatic diseases and 5% ...

DNA mismatch repair in cancer immunotherapy - Oxford Academic

However, in cells defective in MMR, these errors remain unpaired and cause frame-shift and other mutations in the next cell cycle. Mutations in genes critical ...

Survival outcome of adjuvant chemotherapy in deficient mismatch ...

The prognostic impact of DNA mismatch repair (MMR) status remains controversial in patients with stage III colon cancer who are treated with ...

Stage III deficient mismatch repair colon patients get greater benefit ...

However, the optimal treatment for early-stage disease is controversial. A lot of studies have proved that MMR not only accelerates the ...

In Mismatch Repair–Deficient Colon Cancer, Side Matters

In addition, mutation in either KRAS or BRAF independently conferred a worse disease-free survival prognosis in mismatch repair–proficient ...