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Impaired behavioural pain responses in hph|1 mice with ...


Impaired behavioural pain responses in hph-1 mice with ... - NCBI

As the hph-1 mouse is a mutant model, having decreased GTP-CH1 activity during the development and throughout life, the role of BH4 in pain ...

Impaired behavioural pain responses in hph-1 mice with inherited ...

In this study, we demonstrate novel evidence that genetic mutations in the GCH1 gene modulate pain-like hypersensitivity.

Impaired behavioural pain responses in hph-1 mice with inherited ...

Table 1 Mechanical hypersensitivity following intraplantar injection of 0.25-1 μg/paw capsaicin in WT mice and hph mice. From: Impaired behavioural pain ...

(PDF) Impaired Behavioural Pain Responses in hph-1 Mice with ...

Pain behavioural analysis of the hph-1 mice showed reduced pain-like responses following intraplantar injection of CFA, formalin and capsaicin; ...

Impaired Behavioural Pain Responses in hph-1 Mice with ...

Impaired Behavioural Pain Responses in hph-1 Mice with Inherited Deficiency in GTP Cyclohydrolase 1 in Models of Inflammatory Pain · Arafat Nasser · Ole J ...

Impaired behavioural pain responses in hph-1 mice with inherited ...

Impaired behavioural pain responses in hph-1 mice with inherited deficiency in GTP cyclohydrolase 1 in models of inflammatory pain. / Nasser, Arafat; Bjerrum, ...

Impaired Behavioural Pain Responses in hph-1 Mice with Inherited ...

Background GTP cyclohydrolase 1 (GTP-CH1), the rate-limiting enzyme in the synthesis of tetrahydrobiopterin (BH4), encoded by the GCH1 gene, ...

Impaired behavioural pain responses in hph-1 mice with inherited ...

Background: GTP cyclohydrolase 1 (GTP-CH1), the rate-limiting enzyme in the synthesis of tetrahydrobiopterin (BH4), encoded by the GCH1 gene, ...

Impaired behavioural pain responses in hph-1 mice with inherited ...

Dive into the research topics of 'Impaired behavioural pain responses in hph-1 mice with inherited deficiency in GTP cyclohydrolase 1 in models of inflammatory ...

Impaired Behavioural Pain Responses in hph-1 Mice with Inherited ...

BackgroundGTP cyclohydrolase 1 (GTP-CH1), the rate-limiting enzyme in the synthesis of tetrahydrobiopterin (BH4), encoded by the GCH1 gene, ...

Table 2 Average weight of WT, heterozygous and homozygous mice ...

From: Impaired behavioural pain responses in hph-1 mice with inherited deficiency in GTP cyclohydrolase 1 in models of inflammatory pain. Genotype. Weight. SEM ...

Impaired neuropathic pain responses in mice lacking the chemokine ...

In models of inflammatory pain, CCR2 knockout mice showed a 70% reduction in phase 2 of the intraplantar formalin-evoked pain response but only a modest (20–30 ...

Altered pain responses in mice lacking α 1E subunit of the ... - PNAS

Although α1E+/− and α1E−/− mice exhibited normal pain behaviors against acute mechanical, thermal, and chemical stimuli, they both showed reduced responses to ...

Deficits in visceral pain and hyperalgesia of mice with a disruption of ...

Tests of other neurogenic inflammatory stimuli in NK1 −/− mice revealed impaired behavioural responses to cyclophosphamide cystitis and no acute reflex ...

Methods Used to Evaluate Pain Behaviors in Rodents - Frontiers

... behavioral responses that could be considered equivalent to pain in humans. ... Assessment of pain and itch behavior in a mouse model of neurofibromatosis type 1.

Differential behavioral response to predator odor in neuropathic ...

We find that neuropathic mice show hypervigilance to PO, confirming previous results. However, we also find increased anxiety responses to neutral odor in ...

Automated home-cage for the evaluation of innate non-reflexive ...

The pain-related impairment in locomotion obtained with this model would increase the potential use of this model as a validated preclinical ...

C57BL/6 substrain differences in formalin-induced pain-like ...

The use of closely related C57BL/6 inbred mouse substrains can facilitate gene mapping of acute nociceptive behaviors in preclinical pain models ...

Ventral hippocampal CA1 modulates pain behaviors in mice with ...

Notably, there was no detectable difference in behavioral responses between different pain modalities (Figure 1D), but the neurons that ...

Altered nociceptive behavior and emotional contagion of pain in ...

BTBR mice demonstrated mixed nociceptive responses with hyporesponsivity to mechanical/thermal stimuli and intraplantar injections of formalin ...