In Vitro Generated Intervertebral Discs

* In Vitro Generated Intervertebral Discs: Toward Engineering Tissue ...

The intervertebral disc (IVD) is composed of nucleus pulposus (NP) surrounded by multilamellated annulus fibrosus (AF), and is located between the vertebral ...

In Vitro Generated Intervertebral Discs: Toward Engineering Tissue ...

An engineered IVD implant with mechanically stable integration between AF lamellae and AF-NP can be generated in vitro.

Generation of an in vitro model of the outer annulus fibrosus ...

The interface between the intervertebral disc and the vertebral cartilage endplate has been overlooked in previous studies which have generated tissue‐ ...

Intervertebral Disc-on-a-Chip as Advanced In Vitro Model ... - Frontiers

In 3D, IVD cells produce their own ECM and generate an environment responsive to mechanical loading. Macroscale loading bioreactors integrating 3D cell ...

A novel in-vitro model of intervertebral disc degeneration using ...

The grade of IVD degeneration produced in each experimental group can be ... Review of the fluid flow within intervertebral discs - How could in vitro ...

In vitro model of distinct catabolic and inflammatory response ...

These results suggest that AF cells may play a major role in the initial degeneration of intervertebral disc.

* In Vitro Generated Intervertebral Discs: Toward Engineering Tissue ...

An engineered IVD implant with mechanically stable integration between AF lamellae and AF-NP can be generated in vitro and its ability to serve as a ...

Generation of an in vitro model of the outer annulus fibrosus ...

Current treatments for degenerative disc disease do not restore full biological functionality of the intervertebral disc (IVD).

Customized composite intervertebral disc scaffolds by integrated 3D ...

In order to evaluate the feasibility of the produced IVD scaffold as a key component for therapeutic implantation of defective IVD, characterizations were ...

Intervertebral Disk Degeneration: The Microenvironment and Tissue ...

(∗) In vitro generated intervertebral discs: toward engineering tissue integration. Tissue Eng. Part A 23, 1001–1010. doi: 10.1089/ten.tea.2016.0433. PubMed ...

In vitro and in vivo evaluation of discogenic cells, an investigational ...

... generated by expanding and modifying cells from adult intervertebral disc tissue (Fig. 1A), specifically nucleus pulposus tissue. These ...

Intervertebral disc - Physiopedia

It is a cushion of fibrocartilage and the principal joint between two vertebrae in the spinal column. There are 23 discs in the human spine: 6 in the cervical ...

An In Vitro Organ Culture Model of the Murine Intervertebral Disc

Automatically generated. Whole organ culture of the intervertebral disc (IVD) preserves the native extracellular matrix, cell phenotypes, and ...

In Vitro Generated Intervertebral Discs: Towards Engineering Tissue ...

In Vitro Generated Intervertebral Discs: Towards Engineering Tissue Integration. November 20, 2020. MSAM U Waterloo. Catalyst137, Unit 320 137 Glasgow St.

Intervertebral Disc Stem/Progenitor Cells: A Promising “Seed” for ...

... produced and released by the intervertebral disc cells. ... intervertebral disc in in vitro cell migration assays, The Spine Journal.

In vivo intervertebral disc deformation: intratissue strain patterns ...

Inter-tissue displacements and strains (Ep1, Ep2, and Esm) produced via cyclic dualMRI depended on the IVD segment level (Fig. 4). IVD x and y ...

Tissue-engineered intervertebral discs produce new matrix ... - PNAS

Engineered IVD Integrated with Neighboring Vertebrae and Produced Extracellular Matrix with Native Levels of Collagen and Proteoglycan in the AF ...

Nucleus of the Intervertebral Disc from Development to Degeneration1

In the foetus and infant, the nucleus contains actively dividing and biosynthetically active notochordal cells. The proteoglycans and other matrix components ...

(PDF) Intervertebral Disc-on-a-Chip as Advanced In Vitro Model for ...

generate an environment responsive to mechanical loading. Macroscale loading bioreactors integrating 3D cell constructs. thus provide more ...

In Vitro Studies for Investigating Creep of Intervertebral Discs under ...

Creep responses of intervertebral discs (IVDs) are essential for spinal biomechanics clarification. Yet, there still lacks a well-recognized investigation ...