In vitro release of vascular endothelial growth factor during platelet ...

Platelet aggregation is a cardinal feature of both vascular repair and vascular disease. During aggregation platelets release a variety of vasoactive ...

This study was undertaken to investigate the hypothesis that VEGF is released by aggregating platelets. We found that VEGF was secreted during the in vitro ...

Methodological variations affect the release of VEGF in vitro and ...

The fibrin network was rough and twisted with exosomic granulations impregnated on its surface. An increase in the concentration of VEGF in the ...

Highly accumulated platelet vascular endothelial growth factor in ...

Immunohistochemical studies for VEGF in the thrombotic region were performed. Results and conclusions: Megakaryocytes and platelets are a very rich source of ...

Methodological variations affect the release of VEGF in vitro ... - PLOS

The present study evaluated the influence of different g-forces and types of tubes in the release of vascular endothelial growth factor (VEGF) from platelet- ...

Aggregating Human Platelets Stimulate Expression of Vascular ...

Platelet-derived products (PDP) released by aggregating human platelets time-dependently and concentration-dependently enhanced VEGF mRNA levels, mainly that ...

Release of the angiogenic cytokine vascular endothelial growth ...

e.g. wound healing, and in tumour metastasis, when platelets adhering to circulating tumour cells may release VEGF at points of adhesion to ...

Constitutive production and thrombin-induced release of ... - PNAS

Thrombin stimulation of megakaryocytes and platelets resulted in rapid release of VEGF within 30 min. We conclude that human megakaryocytes produce and secrete ...

Highly accumulated platelet vascular endothelial growth factor in ...

Platelet-rich plasma and washed platelets were used to analyze the secretion of VEGF during platelet aggregation by thrombin or gelatinase A (matrix ...

Vascular endothelial growth factor measured in platelet poor plasma ...

[39] who showed that ex vivo generated megakaryocytes and platelets release VEGF upon stimulation with thrombin. Verheul et al. [40] also provided evidence for ...

Vascular endothelial growth factor platelet counts, and prognosis in ...

Patients with platelet counts above the median for the group had a worse prognosis (p=0·027) (figure, B—log rank analysis). A strong positive correlation was ...

The influence of platelet-derived products on angiogenesis and ...

Platelets release main regulators of angiogenesis: Vascular Endothelial Growth Factors (VEGFs), basic fibroblast growth factor (FGF-2), and Platelet derived ...

and antiangiogenic proteins are organized into separate platelet α ...

Double immunofluorescence labeling of vascular endothelial growth factor (VEGF) (an angiogenesis stimulator) and endostatin (an angiogenesis inhibitor), or for ...

Imbalance between Platelet Vascular Endothelial Growth Factor and ...

One speculative role for VEGF in platelets is promotion of vascular repair and wound healing in conjunction with PDGF. Platelet VEGF and PDGF ...

Highly accumulated platelet vascular endothelial growth factor in ...

Gelatinase A, which is closely associated with vascular remodeling, enhances the VEGF levels released from platelets. VEGF was clearly detected in the fibrin.

Vascular endothelial growth factor–stimulated endothelial cells ...

The occurrence of platelet adhesion after 6 hours of stimulation of confluent endothelial cells with either VEGF or bFGF in a dose range from ...

The transport of high amounts of vascular endothelial growth factor ...

Results. Platelets from SSc patients, in contrast to controls, secreted large amounts of VEGF when activated, but not PDGF-BB, TGF-β1 or ...

Combination of Vascular Endothelial Growth Factor Receptor ...

Results: Combined inhibition of VEGF and PDGF signaling resulted in enhanced apoptosis, reduced cell proliferation, and clonogenic survival as well as reduced ...

Sustained Release of Vascular Endothelial Growth Factor from Poly ...

In this study, we have developed monodisperse VEGF-loaded microspheres that exhibit sustained release kinetics for 4 weeks. This release ...

Platelets and Granulocytes, in Particular the Neutrophils, Form ...

Vascular endothelial growth factor (VEGF) is released from platelets during blood clotting: Implications for measurement of circulating VEGF levels in clinical ...