Increase in thiol oxidative stress via glutathione reductase inhibition ...

Depletion of the reduced form of glutathione (GSH) has been extensively studied for its effect on sensitizing cancer to radiation.

Increase in Thiol Oxidative Stress via Glutathione Reductase ...

Inhibition of this enzyme has been demonstrated to lead to an accumulation of GSSG creating a state of thiol oxidative stress [32,33]. However, ...

Abstract. Depletion of the reduced form of glutathione (GSH) has been extensively studied for its effect on sensitizing cancer to radiation. However, little is ...

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Increase in thiol oxidative stress via glutathione reductase inhibition as a novel approach to enhance cancer sensitivity to X-ray irradiation. | Academic ...

Increase in Thiol Oxidative Stress via Glutathione Reductase ...

Request PDF | Increase in Thiol Oxidative Stress via Glutathione Reductase Inhibition as a Novel Approach to Enhance Cancer Sensitivity to ...

Increase in thiol oxidative stress via glutathione reductase inhibition ...

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Glutathione reductase-mediated thiol oxidative stress suppresses ...

Inhibition of GR induced oxidative stress which suppresses melanoma cells lung metastasis and subcutaneous growth in vivo.

Increased Expression of Glutathione Reductase in Macrophages ...

Thiol oxidative stress leads to macrophage dysfunction and cell injury, and has been implicated in the development of atherosclerotic lesions. We show that ...

"Evaluation and Applications of a Novel Glutathione Reductase ...

Thiol redox state (TRS) refers to the balance between reduced thiols and their corresponding disulfides, and is mainly reflected by the ratio of GSH/GSSG.

Effects of glutathione reductase inhibition on cellular thiol redox ...

Although inhibition of glutathione reductase (GR) has been demonstrated to cause a decrease in reduced glutathione (GSH) and increase in glutathione ...

Cytoplasmic glutathione redox status determines survival upon ...

GSSG concentrations can increase during oxidative stress (Sies, 1972). The ubiquitous enzyme glutathione reductase (GR; EC 1.6.4.2) uses the reducing ...

Thiols: Role in Oxidative Stress-Related Disorders | IntechOpen

There are a wide variety of powerful antioxidants that cells use, such as vitamins (C, E, A) and enzymes (CAT, GPx, SOD and thioredoxin reductase). Other non- ...

Evaluation of a dithiocarbamate derivative as a model of thiol ...

Results indicated that 2-AAPA effectively inhibited glutathione reductase and thioredoxin reductase activities and decreased the GSH/GSSG ratio by causing a ...

Thiol-based mechanisms of the thioredoxin and glutaredoxin systems

Key players in defense against oxidative stress are members of the thioredoxin-fold family of proteins. Of these, thioredoxins and glutaredoxins maintain a ...

Characterization of a Novel Dithiocarbamate Glutathione Reductase ...

Inhibition of the enzyme leads to accumulation of GSSG and an increase in intracellular thiol oxidative stress. Therefore, a GR inhibitor will ...

Missing links in understanding redox signaling via thiol/disulfide ...

Most attention has focused on the ascorbate-glutathione pathway, but several other candidate pathways may couple the availability of oxidants such as H2O2 to ...

A crucial role for thiol antioxidants in estrogen-deficiency bone loss

The 17-β estradiol increased glutathione and glutathione and thioredoxin reductases in osteoclast-like cells in vitro. ... Ascorbic acid prevents oxidative stress ...

Among them are glutaredoxins, which are central in the response against oxidative stress as the biological activity of many proteins are modified by the ...

Glutathione in cancer progression and chemoresistance: an update in

Moreover, it has been reported that GSH sequestration in the nucleus correlates with a reduced transcription of genes encoding for stress and ...

Oxidative stress and redox regulation of lung inflammation in COPD

Glutathione peroxidase reduces H2O2 to H2O by oxidising glutathione as shown in equation 1. Re-reduction of the oxidised form of GSSG is then catalysed by ...