Incretin Effects on β|Cell Function

Incretin Effects on β-Cell Function, Replication, and Mass

Incretin hormones, which are released from the gastrointestinal tract after a meal, enhance glucose-dependent insulin secretion from the pancreas.

Incretin and Pancreatic β-Cell Function in Patients with Type 2 ...

Among them, the action of incretin hormones, known as the incretin effect, contributes to 50% to 70% of insulin secretion after the oral ...

β-Cell Function, Incretin Effect, and Glucose Kinetics in Response to ...

SAXA+DAPA provided superior glycemic control compared with DAPA or SAXA, with improved β-cell function, insulin sensitivity, GLP-1 availability, and glucose ...

The Incretins and β-Cell Health: Contrasting Glucose-Dependent ...

The incretin effect, augmentation of glucose-stimulated insulin secretion by factors released from the gastrointestinal tract, is a phenomenon identified nearly ...

β-Cell Function, Incretin Effect, and Incretin Hormones in Obese ...

The key finding of the current studies is that youth with IGT or T2D have a reduced incretin effect compared with their NGT peers without ...

Impact of incretin hormones on β-cell function in subjects with ...

The incretin effect was taken to be the ratio of oral to IV responses. In NGT, incretin-mediated insulin release [oral glucose tolerance test (OGTT)/IV ratio = ...

Incretin - an overview | ScienceDirect Topics

Finally, because of the pleiotropic effects of the incretin hormones on the β-cell and the inhibition of glucagon secretion by GLP-1, enhancement of incretin ...

The effects of incretin‐based therapies on β‐cell function and insulin ...

Conclusions. Incretin-based therapies not only show an increase in HOMA-β and fasting C-peptide level, but also achieve a reduction in HOMA-IR ...

Review The biology of incretin hormones - ScienceDirect.com

Both GIP and GLP-1 also promote β cell proliferation and inhibit apoptosis, leading to expansion of β cell mass. GLP-1, but not GIP, controls glycemia via ...

Role of Incretins on Insulin Function and Glucose Homeostasis

Abstract. The incretin effect—the amplification of insulin secretion after oral vs intravenous administration of glucose as a mean to improve glucose toler.

Incretin Therapies: Effects Beyond Glycemic Control

Recent science has elaborated on the role of the incretin hormones on β-cell function and insulin secretion, as well as the role that incretin-based.

GIP mediates the incretin effect and glucose tolerance by dual ...

Moreover, we demonstrate that GIP activity in α cells contributes to insulin secretion by invoking paracrine α to β cell communication. Last, ...

The Incretin Effect - Glucagon.com

Thus, incretins are hormones that are secreted from the gastrointestinal tract into the circulation in response to nutrient ingestion that ...

Effects of Incretin Hormones on β-Cell Mass and Function, Body ...

The incretin hormone–based therapies are novel therapeutic agents for the treatment of type 2 diabetes, because they not only improve glycemia with minimal risk ...

Assessing the Effect of Incretin Hormones and Other Insulin ... - MDPI

However, to our knowledge, no previous study reviewed the mathematical models focused on the effect on insulin secretion and beta-cell function ...

The incretin system in healthy humans: The role of GIP and GLP-1

The incretin effect, the amplification of insulin secretion occurring when glucose is taken in orally as compared to infused intravenously, is ...

Impaired beta-cell function, incretin effect, and glucagon ...

The patients with type 1 diabetes had fasting glucose, insulin, and glucagon values similar to those of control subjects. Additionally, the insulin secretory ...

Incretin pathway regulates β-cell survival - Nature

Newly published data have shown that the incretin hormone glucose-dependent insulinotropic polypeptide (GIP) promotes β-cell function and survival via ...

Detour Ahead: Incretin Hormone Signaling Alters Its Intracellular ...

GCGR thus functions akin to an incretin hormone. Whether and how GCGR signaling changes during diabetes is unknown. The role of glucagon in β-cell (dys-) ...

Effects of incretin-based therapies on β-cell function in type 1 ...

This meta-analysis showed that incretin-based therapies did not preserve β-cell function in patients with T1DM.