Induction and modulation of the unfolded protein response during ...

Porcine deltacoronavirus (PDCoV) is an emerging enteropathogenic coronavirus that has the potential for cross-species infection.

We found that PDCoV infection induced ERS and activated all three known UPR pathways (inositol-requiring enzyme 1 [IRE1], activating transcription factor 6 [ ...

Induction of the unfolded protein response (UPR) during ...

Examination of the three branches of the UPR revealed that the IRE1-XBP1 and eIF2α-ATF4 pathways were activated during PRV infection. In addition, PRV induced ...

Induction of unfolded protein response during neuronal ... - Nature

Our results showing the induction of UPR during neuronal differentiations of rBMSCs and mES cells as well as NF-L expression by ER stress inducers strongly ...

Unfolded protein response‐mediated modulation of mesenchymal ...

The UPR is mediated through three primary pathways: activating transcription factor-6, inositol-requiring enzyme-1 (IRE1), and PKR-like ...

Modulation of the Unfolded Protein Response by the Severe Acute ...

A substantial amount of S protein accumulates in the ER. The expression of S protein exerts different effects on the three major signaling pathways of the UPR.

Induction of the Unfolded Protein Response Drives Enhanced ...

The unfolded protein response (UPR) is an endoplasmic reticulum (ER)-based cytoprotective mechanism acting to prevent pathologies accompanying protein ...

Modulation of the unfolded protein response impedes tumor cell ...

4c), and under normal conditions, UPR modulation did not alter cell viability in HepG2 cells. However, following ER stress induction, PERKi, but ...

Modulation of SARS-CoV-2 Spike-induced Unfolded Protein ...

We noticed, in the transfected cells, heightened ER stress, activation of the PERK-eIF2α arm of the UPR, induction of autophagy and cell death.

Deciphering ER stress-unfolded protein response relationship by ...

Our reporter enables us to clarify the involvement of unfolded proteins in UPR activation under several physiological conditions and suggests that persistent ...

The unfolded protein response in neurodegenerative disorders ...

The unfolded protein response (UPR) is a highly conserved protein quality control mechanism, activated in response to Endoplasmic Reticulum ...

PERK mediates cell-cycle exit during the mammalian unfolded ...

The UPR coordinates the induction of ER chaperones with decreased protein synthesis and growth arrest in the G1 phase of the cell cycle. Three ER transmembrane ...

Targeting unfolded protein response: a new horizon for disease ...

During persistent ER stress, IRE1 plays a role in switching pro-survival signalling to pro-apoptotic signalling with the induction of a reactive ...

Structure and Molecular Mechanism of ER Stress Signaling by the ...

In metazoans there are three key UPR signal activator proteins: inositol requiring enzyme 1α/β (IRE1) (Cox et al., 1993; Mori et al., 1993), PKR-like ER kinase ...

Endoplasmic Reticulum Stress and Unfolded Protein Response in ...

Perturbations in the ER (ER stress) lead to a signaling cascade termed unfolded protein response (UPR), aimed at restoring cell homeostasis. The UPR pathways ...

Intrinsic Capacities of Molecular Sensors of the Unfolded Protein ...

The yeast S. cerevisiae senses unfolded proteins with a single sensor, IRE1 (Cox, 1993; Mori, 1993). In mammalian cells, the UPR response is ...

Coronavirus Infection Modulates the Unfolded Protein Response ...

We hypothesized that the association and intense utilization of the ER during viral replication would induce the cellular unfolded protein response (UPR), a ...

(PDF) Assays for Induction of the Unfolded Protein Response and ...

Stimuli that disrupt ER function cause an accumulation of misfolded proteins within the ER lumen, a condition termed ER stress. The unfolded protein response ( ...

Effect of modulation of unfolded protein response pathway on ...

During the ER stress, BiP dissociates from the UPR element(s) resulting in the activation of the element(s) and induction of UPR. Activation of ...

Modulation of endoplasmic reticulum stress and the unfolded protein ...

We found a large transcriptional reprogramming in the cell lines and of the genes affected, those involved in endoplasmic reticulum stress and ...