Induction of IL|9 in Peripheral Lymphocytes of Rheumatoid Arthritis ...

Induction of IL-9 in Peripheral Lymphocytes of Rheumatoid Arthritis ...

The results indicate that Th9- and Th17-inducing cytokine conditions mimicking autoimmune inflammation in RA may have similar stimulatory effects.

(PDF) Induction of IL-9 in Peripheral Lymphocytes of Rheumatoid ...

In conclusion, the results indicate that Th9- and Th17-inducing cytokine conditions mimicking autoimmune inflammation in RA may have similar ...

Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid ...

The inhibitor of PU.1 and IL-9 blocking antibody was used in collagen-induced arthritis (CIA). In an in vitro study, the effects of IL-9 ...

Potential involvement of IL-9 and Th9 cells in the pathogenesis of ...

Results. IL-9 was overexpressed in RA synovial tissues and correlated with the degree of histological organization of B and T cells in ectopic ...

Negative impact of Interleukin-9 on synovial regulatory T cells in ...

Blocking the IL-9 may constitute a novel therapeutic approach for inhibiting synovial inflammation in RA. Abstract. In Rheumatoid Arthritis (RA), regulatory T ...

Synovial IL-9 facilitates neutrophil survival, function and ...

Very recently, Th9 cells have been identified in rheumatoid arthritis (RA) peripheral blood and synovial tissues and fluid, but their ...

Interleukin-9 and T helper type 9 cells in rheumatic diseases

IL-9 expression has been found mainly among synovial fibroblasts and infiltrating mononuclear cells. Th9 cells were demonstrated to be the main source of IL-9 ...

IL-37 Alleviates Rheumatoid Arthritis by Suppressing IL-17 and IL ...

rhIL-37 markedly decreased IL-17 expression and Th17 cell frequency in PBMCs and CD4+ T cells from RA patients. Furthermore, IL-37 exerted a more suppressive ...

Interleukin-7 deficiency in rheumatoid arthritis: consequences for ...

Interleukin-7 (IL-7) is known to stimulate the thymus to produce new T-cells and to allow circulating mature T-cells to expand, thereby playing ...

Longitudinal relationships between rheumatoid factor and cytokine ...

Our findings suggest that RF expression sustained over time increases activation of B cells and monocytes without requirements for T-cell functions.

A Tale of Two Immune Cells in Rheumatoid Arthritis - Frontiers

3) induction of hyper-activation of T cells by monocytes/macrophages: IL-15 lead to increased expression of MHCII and reduced expression of ...

Interleukin 4 inhibits polyclonal immunoglobulin secretion and ...

Interleukin 4 inhibits polyclonal immunoglobulin secretion and cytokine production by peripheral blood mononuclear cells from rheumatoid arthritis patients.

Immunomodulatory role of T helper cells in rheumatoid arthritis

IL-17A induces secretion of the proinflammatory cytokines TNF-α, IL-1b, IL-6, and IL-8 by macrophages, fibroblasts, chondrocytes, stromal cells, ...

AB0100 Mtx combined with ctx inhibited il-6 induced jak2-stat3 ...

... induction of p-gp in peripheral blood lymphocytes of rheumatoid arthritis patients. Free. Loading. K Chen,; Y Mu,; K Qin,; X Zhao,; J Dong,; X Li, ...

Update on the Pathomechanism, Diagnosis, and Treatment Options ...

Especially TNF-α, which is also produced by synovial macrophages, B-, and NK-cells is one of the most important mediators of joint inflammation in RA [60]. It ...

TNF-α blockade induces IL-10 expression in human CD4+ T cells

We have previously shown that patients with rheumatoid arthritis (RA) have an increased percentage of IL-17+IFN-γ- CD4+ T cells in their ...

Characterization of interleukin‐7 and interleukin‐7 receptor in the ...

IL-7 and IL-7R were coexpressed on RA synovial tissue lining and sublining macrophages and endothelial cells. Expression of IL-7 and its ...

Rheumatoid arthritis synovial T cells regulate transcription of ... - JCI

Following anti–TNF-α therapy in vivo, RA PBMC Calmodulin transcripts increased five- to tenfold. Pharmacological calmodulin blockade in vitro impaired antigen- ...

IL-17–producing human peripheral regulatory T cells retain ...

Short-term mitogenic activation was sufficient to induce IL-17 secretion in ex vivo DR− Tregs, indicating that FoxP3+IL-17+ cells are fully differentiated IL-17 ...

Cytokine Blockade as a New Strategy to Treat Rheumatoid Arthritis

Moreover, anti-TNF antibody was demonstrated in 1989 to inhibit production of IL-1 by synovial cells in culture. The reciprocal regulation of TNF production by ...